{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:36:04Z","timestamp":1788428164889,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a prevalent skin pigmentation disorder that is difficult to treat. Tranexamic acid (TA) is a potential agent, but there are few studies on its effectiveness under the transdermal route (drug delivery\u2014Dd). One of these Dd pathways is through microneedling, which seems to be effective itself.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of tranexamic acid when applied in the form of drug delivery through microneedling in the treatment of facial melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized controlled double\u2010blind split\u2010face trial with 3\u00a0monthly sessions in 20\u00a0melasma patients: microneedling was performed in the entire face, and then TA solution was applied to one hemiface and placebo to the other. The effectiveness was measured using Hemi\u2010MASI (Melasma Area and Severity Index), images pixels, and perceptions of experts and patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hemi\u2010MASI regressed 22% in control and 29% in TA side. A good\/better improvement was found in 37.5% of the control and 42.5% of TA by the experts and 60% of the patients for both sides. Pixels increased by 5 and 7, respectively. In none of these criteria, there was a significant difference between the sides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tranexamic acid in drug delivery through microneedling did not bring additional benefit to the treatment of melisma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14257","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T21:46:58Z","timestamp":1622670418000},"page":"4005-4010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Randomized, double\u2010blind, placebo\u2010controlled split\u2010face trial of the efficacy of tranexamic acid by drug delivery through microneedling in the treatment of melasma"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-245X","authenticated-orcid":false,"given":"D\u00e2mia","family":"Kuster Kaminski Arida","sequence":"first","affiliation":[{"name":"Department of Dermatology of Hospital Universit\u00e1rio Evang\u00e9lico Mackenzie  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-2273","authenticated-orcid":false,"given":"Priscila Regina","family":"Orso Rebellato","sequence":"additional","affiliation":[{"name":"Department of Dermatology of Hospital Universit\u00e1rio Evang\u00e9lico Mackenzie  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana Liz","family":"Marioto de Campos","sequence":"additional","affiliation":[{"name":"Department of Dermatology of Hospital Universit\u00e1rio Evang\u00e9lico Mackenzie  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriane","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Dermatology of Hospital Universit\u00e1rio Evang\u00e9lico Mackenzie  Curitiba 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Universit\u00e1rio Evang\u00e9lico Mackenzie  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20143063"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0263-3"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"174","article-title":"Estudo de avalia\u00e7\u00e3o da efic\u00e1cia do \u00e1cido tranex\u00e2mico t\u00f3pico e injet\u00e1vel no tratamento do melasma","volume":"1","author":"Steiner D","year":"2009","journal-title":"Surg Cosm Dermatol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04464.x"},{"issue":"4","key":"e_1_2_8_7_1","first-page":"1","article-title":"Efficacy and safety of tranexamic acid in melasma: a meta\u2010analysis and systematic 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