{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:35:25Z","timestamp":1791506125918,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010mobility group box 1 (HMGB1)\u2010receptor for advanced glycation end (RAGE)\u2010moesin axis could be implicated in induction of inflammation. However, there is a scarcity in literature discussing the role of this axis in inflammatory skin disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the present study was to evaluate the serum levels of HMGB1 and moesin in patients with inflammatory acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This comparative cross\u2010sectional study included 66 inflammatory acne vulgaris patients classified according to Global Acne Grading System (GAGS) into three groups (22 patients each): mild, moderate, and severe acne vulgaris. In addition, 82 acne\u2010free individuals were included as a control group. Serum HMGB 1 and moesin levels were measured using enzyme\u2010linked immunosorbent assay kits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High\u2010mobility group box 1 and moe sin serum levels in acne patients were significantly higher than the levels in control subjects (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04, 0.0005 respectively). Serum levels of both markers in severe acne patients and in those with post\u2010acne scarring were elevated when compared to the levels in the other groups, and however, this elevation was significant only for moesin levels. There was a significant positive correlation between the serum levels of HMGB1 and moesin in the studied patient's sample (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.3079, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010mobility group box 1\u2010receptor for advanced glycation end\u2010moesin axis may be implicated in acne vulgaris pathogenesis, and it may be a promising therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14261","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T10:24:06Z","timestamp":1622802246000},"page":"1642-1646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["HMGB1\u2010RAGE\u2010moesin axis may be indicted for acne vulgaris"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-1224","authenticated-orcid":false,"given":"Rehab Mohammed","family":"Salem","sequence":"first","affiliation":[{"name":"Department of Dermatology and Andrology Faculty of Medicine\u2010 Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa Adel","family":"El\u2010fallah","sequence":"additional","affiliation":[{"name":"Department of Chemical and Clinical Pathology Faculty of Medicine\u2010 Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Shaker","sequence":"additional","affiliation":[{"name":"Department of Public Health Faculty of Medicine\u2010 Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S205170"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001265"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1330-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-012-0901-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2119\/2006-00108.Goldstein"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5230374"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2578-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2312-2320.2004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/09680519010070041001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0259"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"350","article-title":"Role of moesin in HMGB1\u2010stimulated severe inflammatory responses","volume":"114","author":"Lee W","year":"2015","journal-title":"Thromb Haemost"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12753"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/ejdv.ejdv_10_17"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.05.020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2013.00164"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.7.3215-3220.1999"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.3.1535"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020348"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23848.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701188"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30093"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31078"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.17116\/jnevro20181181214"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.167272"},{"issue":"6","key":"e_1_2_8_27_1","first-page":"42","article-title":"Fulminans in dermatology: a call to action. A recommendation for consideration of the term Scleredema Fulminans","volume":"7","author":"Sommer LL","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.160256"},{"issue":"1","key":"e_1_2_8_29_1","first-page":"31","article-title":"Type I and type II acute\u2010phase proteins in acne vulgaris","volume":"16","author":"El\u2010Taweel A","year":"2019","journal-title":"JEWDS"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13011"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101323"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14261","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:00:36Z","timestamp":1692874836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/jocd.14261"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14261","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]},"assertion":[{"value":"2020-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}