{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:45:17Z","timestamp":1791938717938,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris (AV) is the most prevalent inflammatory skin disease and develops on the face and upper trunk. Resistin, a member of the cysteine\u2010rich secretory proteins family, is an adipokine expressed primarily in macrophages and monocytes; it has a role to play in the inflammatory period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study's purpose was to detect whether known resistin gene (\u2212420\u2009C\u00a0&gt;\u00a0G) polymorphism plays a role in the pathogenesis of AV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with AV (<jats:italic>n<\/jats:italic>\u00a0=\u00a094) and healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a094) were enrolled in this investigation. Resistin gene (\u2212420\u2009C\u00a0&gt;\u00a0G) polymorphism was decided by PCR\u2010RFLP procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of genotype frequencies of resistin gene (\u2212420\u2009C\u00a0&gt;\u00a0G) polymorphism was significantly different between the AV and healthy controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). We found that the resistin gene (\u2212420\u2009C\u00a0&gt;\u00a0G) CG genotype exhibited a significant association with decreased acne vulgaris risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study is the first report investigating the relationship between the risk of AV and resistin gene (\u2212420\u2009C\u00a0&gt;\u00a0G) polymorphism in the Turkish population. Resistin gene (\u2212420\u2009C\u00a0&gt;\u00a0G) polymorphism is related to AV pathogenesis. CG genotype has a protective role and may be linked to a reduced risk of AV development. Furthermore, studies are needed to verify these findings in other populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14264","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T09:18:06Z","timestamp":1622452686000},"page":"1651-1655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between resistin gene (\u2212420\u2009C\u00a0&gt;\u00a0G) polymorphism and acne vulgaris"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-1945","authenticated-orcid":false,"given":"Raziye","family":"Akc\u0131lar","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of K\u00fctahya Health Sciences  K\u00fctahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazl\u0131","family":"Dizen Namdar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of K\u00fctahya Health Sciences  K\u00fctahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selve","family":"Arslan Utku","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of K\u00fctahya Health Sciences  K\u00fctahya 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