{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:34:05Z","timestamp":1747186445589,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Some studies have investigated the relationship between Beh\u00e7et's disease (BD) and insulin resistance; however, since they did not exclude obese patients from their sample, it remains unclear whether BD itself causes insulin resistance independently of obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 60 patients with BD and 45 age\u2010, gender\u2010, and body mass index (BMI)\u2013matched healthy controls. Obese patients with a BMI of \u226530\u00a0kg\/m\u00b2 were excluded. Insulin resistance according to the homeostasis model assessment for insulin resistance (HOMA\u2010IR) and quantitative insulin sensitivity check index (QUICKI), fasting plasma glucose, and one\u2010hour and two\u2010hour plasma glucose in the oral glucose tolerance test (OGTT 1\u2010h and OGTT 2\u2010h PG, respectively) were evaluated in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean fasting plasma glucose levels and the rate of those with impaired glucose tolerance according to OGTT 2\u2010h PG were significantly higher in the BD patients compared to the controls. The rates of those with insulin resistance according to HOMA\u2010IR and QUICKI were significantly higher in the BD patients than in the controls. When compared to the control group, the rates of those with impaired fasting glucose and impaired glucose tolerance were significantly higher, and the mean QUICKI value was significantly lower in the active group, in contrast to the inactive group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Insulin resistance occurs in BD patients independently of obesity. In the follow\u2010up of BD patients, especially in the active phase, not only fasting blood glucose but also other diagnostic tests for insulin resistance should be added to the examination panels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14276","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T18:58:05Z","timestamp":1622833085000},"page":"1688-1694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Do nonobese patients with Beh\u00e7et\u2019s disease have insulin resistance?"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9109-3892","authenticated-orcid":false,"given":"Filiz","family":"Cebeci Kahraman","sequence":"first","affiliation":[{"name":"Department of Dermatology G\u00f6ztepe Prof. Dr. S\u00fcleyman Yal\u00e7\u0131n City Hospital Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-2636","authenticated-orcid":false,"given":"Kadir","family":"Kayata\u015f","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Haydarpa\u015fa Numune Training and Research Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4392-4671","authenticated-orcid":false,"given":"Sevil","family":"Sava\u015f Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sultan 2. 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