{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:40:24Z","timestamp":1784817624373,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Over the years, botulinum toxin has found its place as a neuromuscular blocking agent in numerous medical fields. Since the approval of botulinum toxin by the FDA for cosmetic indications in 2002, it had become the most commonly performed esthetic procedure worldwide, with ever\u2010growing demand. The characteristics of the toxin, along with the facial areas it is injected to, could possibly account for a wide array of complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors conducted a literature search for reported cases of ophthalmic adverse events following Botulinum toxin facial injections in the electronic databases of PubMed and Cochrane Library databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The authors found 25 publications, reporting 49 cases of ophthalmic adverse events following botulinum toxin injections. Injections for cosmetic indications accounted for 51% of all injections, treatment of blepharospasms for 22% of cases, protective ptosis for 11% of cases, and treatment of hemifacial spams for 8% of cases. The average quantity of botulinum toxin injected to a single patient ranged between 1.25 and 75 units, with a median of 13.75 units.Majority of injections for cosmetic indications were performed to the lateral canthal area (56%), followed by the glabella (28%) and the forehead (20%).Adverse events following injections included diplopia (64%), ptosis (14%), and decrease in visual acuity or vision loss (8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Botulinum toxin is gaining extreme popularity in the management of a wide area of diseases and for cosmetic indications. Proper knowledge of potential adverse events is crucial for the clinician in attempt to decrease complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14279","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T17:24:57Z","timestamp":1623086697000},"page":"2409-2413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ophthalmic adverse events following facial injections of botulinum toxin A: A systemic literature review"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-9967","authenticated-orcid":false,"given":"Ron","family":"Skorochod","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shaare\u2010Zedek Medical Center  Jerusalem Israel"},{"name":"The Hebrew University Medical School  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Nesher","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Meir Medical Center  Kfar\u2010Saba Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Nesher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine A and the Rheumatology Unit Shaare\u2010Zedek Medical Center  Jerusalem Israel"},{"name":"The Hebrew University Medical School  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Gronovich","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shaare\u2010Zedek Medical Center  Jerusalem Israel"},{"name":"The Hebrew University Medical School  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04821.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.105567"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)00216-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2021.00003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1954.sp005067"},{"issue":"12","key":"e_1_2_7_7_1","first-page":"924","article-title":"Pharmacologic weakening of extraocular muscles","volume":"12","author":"Scott AB","year":"1973","journal-title":"Invest Ophthalmol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198908000-00027"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1992.tb03295.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-19970701-10"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000475758.63709.23"},{"key":"e_1_2_7_12_1","unstructured":"American Society of Plastic Surgeons\u2019 National Clearinghouse of Plastic Surgery Procedural Statistics.2019. 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