{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:09:29Z","timestamp":1785186569036,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Minoxidil is a widely used over\u2010the\u2010counter topical treatment for hair loss. The response rate for topical minoxidil is relatively low. Minoxidil is a pro\u2010drug, converted to its active form, minoxidil sulfate, by SULT1A1 enzymes located in the scalp. Recently, a novel topical formula that increases the activity of SULT1A1 in hair follicles was reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate any benefit of applying the SULT1A1 enzyme booster prior to daily 5% minoxidil treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male androgenic alopecia patients were recruited to a randomized blinded placebo\u2010controlled study. Patients were randomized to receive 5% topical minoxidil plus the novel formula or minoxidil plus a sham adjuvant. Patient's hair growth was monitored using global photography over 60\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four males with androgenic alopecia (Norwood scale average 4.4, range 2\u20136) were randomized and completed the trial: 12 in the active arm and 12 in placebo. 75% of the subjects who used the SULT1A1 adjuvant with their daily minoxidil treatments for 60\u00a0days regrew hair versus 33% of those using the placebo adjuvant (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a small cohort of androgenetic alopecia men, adding the SULT1A1 adjuvant to their daily minoxidil treatment regimen improved hair regrowth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14299","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T17:41:36Z","timestamp":1623865296000},"page":"343-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["SULT1A1 (Minoxidil Sulfotransferase) enzyme booster significantly improves response to topical minoxidil for hair regrowth"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-8043","authenticated-orcid":false,"given":"Rachita","family":"Dhurat","sequence":"first","affiliation":[{"name":"Department of Dermatology LTM Medical College &amp; Hospital Sion Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanober","family":"Daruwalla","sequence":"additional","affiliation":[{"name":"Department of Dermatology LTM Medical College &amp; Hospital Sion Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Dermatology LTM Medical College &amp; Hospital Sion Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-5535","authenticated-orcid":false,"given":"Maja","family":"Kovacevic","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Center \u201cSestre milosrdnice\u201d Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1577-9910","authenticated-orcid":false,"given":"John","family":"McCoy","sequence":"additional","affiliation":[{"name":"Applied Biology Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Dermatology New York University Langone Medical Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne East Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Vano\u2010Galvan","sequence":"additional","affiliation":[{"name":"Trichology Unit Dermatology Department Ramon y Cajal Hospital IRYCIS University of Alcala Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8190-2289","authenticated-orcid":false,"given":"Andy","family":"Goren","sequence":"additional","affiliation":[{"name":"Applied Biology Irvine California USA"},{"name":"Department of Dermatology and Venereology Clinical Hospital Center Sestre Milosrdnice Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"issue":"136","key":"e_1_2_10_2_1","article-title":"The effectiveness of treatments for androgenetic alopecia: a systematic review and meta\u2010analysis","volume":"77","author":"Adil A","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.012"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13630"},{"key":"e_1_2_10_5_1","unstructured":"MannD.Survey: Most Baldness Treatments Don't Work.https:\/\/www.webmd.com\/skin\u2010problems\u2010and\u2010treatments\/hair\u2010loss\/news\/20100406\/survey\u2010most\u2010baldness\u2010treatments\u2010dont\u2010work#1. 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