{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:48Z","timestamp":1791895608285,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous unit that affects over 80% of adolescents and young adults. This study aimed to compare the therapeutic efficacy and tolerability of an isotretinoin treatment course with GDP\u201020 (granulysin\u2010derived peptides) versus the conventional isotretinoin monotherapy prescribed to patients with mild\u2010to\u2010moderate acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study included 60 Russian subjects affected with AV of mild\u2010to\u2010moderate severity divided into two therapeutic groups. Half of the patients were female; mean age was 19.5\u00a0\u00b1\u00a05.6\u00a0years. Group 1 was treated with topical GDP\u201020 twice daily to the affected skin of the face combined with systemic isotretinoin in a fixed low dose of 0.3\u00a0mg\/kg\/day. Group 2 was treated with systemic isotretinoin as a monotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The assessment of the changes of AV lesion count on the 12th week of the treatment showed that in Group 1, the mean value of open comedo number reduced from 21.4\u00a0\u00b1\u00a06.1 at day 0 to 4.4\u00a0\u00b1\u00a02.5 (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05), the mean number of closed comedo reduced from 7.6\u00a0\u00b1\u00a03.5 to 2.4\u00a0\u00b1\u00a01.05 (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05), and those of papules\u2010pustules reduced from 6.1\u00a0\u00b1\u00a01.03 to 1.4\u00a0\u00b1\u00a00.2 (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical antimicrobial peptides (GDP\u201020) combined with low doses of systemic isotretinoin mild\u2010to\u2010moderate resulted in considerable improvement of clinical manifestations of mild\u2010to\u2010moderate AV and threefold reduction in the disease severity with IGA score 0\u20131 after 12\u00a0weeks. Topical application of GDP\u201020 antimicrobial peptides can improve the efficacy of low\u2010dose systemic isotretinoin in combined treatment of mild\u2010to\u2010moderate AV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14300","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T15:00:08Z","timestamp":1624028408000},"page":"1533-1538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Topical antimicrobial peptides in combined treatment of acne patients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7931-3258","authenticated-orcid":false,"given":"Ziyuan","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Skin and Venereal Diseases named after V.A. Rakhmanov Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay","family":"Kochergin","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases named after V.A. Rakhmanov Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Olisova","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases named after V.A. Rakhmanov Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Snarskaya","sequence":"additional","affiliation":[{"name":"Department of Skin and Venereal Diseases named after V.A. Rakhmanov Sechenov First Moscow State Medical University (Sechenov University)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.446"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12149"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9020144"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62715-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13188"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2020.11.008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.11.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-8990.210700"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.051"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17228524"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12912"},{"key":"e_1_2_9_14_1","first-page":"3","article-title":"Overview 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