{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:45:21Z","timestamp":1791938721539,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Different Matrix metalloproteinases (MMPs) family members may be implicated in acne vulgaris development. However, there are no published data about the role of MMP\u20101 and TIMP\u20101\u00a0gene polymorphisms in acne vulgaris development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the association between MMP\u20101 (519 A\/G) and TIMP\u20101 (372\u00a0T\/C) gene polymorphisms and the risk of developing acne vulgaris among a sample of Egyptian acne patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>This case\u2010control study included 100 acne vulgaris patients and 120 apparently healthy control subjects. Acne severity was assessed according to Global Acne Grading System (GAGS). MMP\u20101 (519 A\/G) and TIMP\u20101 (372\u00a0T\/C) gene polymorphisms were investigated using RFLP\u2010PCR technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MMP\u20101 (519 A\/G) AG and GG genotypes and G allele increase the risk of acne vulgaris~2\u20133 folds. In female patients, TIMP\u20101 (372 C\/T) TT genotype and T allele showed significantly higher frequency in cases compared with the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004, 0.001 respectively) with a higher risk to develop acne. On the other hand, in male patients, there was insignificant difference between the frequency of alleles in patients and control subjects. TIMP\u20101 (372C\/T) TT genotype has been shown to be significantly detected in the studied female patients associated with the positive family history of the disease, and it increases the risk of back affection, severe acne grade development, and the liability to postacne scar formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MMP\u20101 (519 A\/G) and TIMP\u20101 (372\u00a0T\/C) gene polymorphisms may be related to acne vulgaris development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14316","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T14:47:37Z","timestamp":1625237257000},"page":"1705-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["MMP\u20101 (519 A\/G) and TIMP\u20101 (372 T\/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Shimaa Moustafa Ali","family":"Mohammed","sequence":"first","affiliation":[{"name":"Dermatology Resident in Kafr Shokr Hospital  Qalubia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Hassan","family":"Sabry","sequence":"additional","affiliation":[{"name":"Dermatology and Andrology Department, Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seham Gouda","family":"Ameen","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology Department, Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-1224","authenticated-orcid":false,"given":"Rehab Mohammed","family":"Salem","sequence":"additional","affiliation":[{"name":"Dermatology and Andrology Department, Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12516"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051313"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.05.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2364581"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.07.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184448"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.01.032"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-187"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01693.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.06.129"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12499"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.160505"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.11.043"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.06.012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-008-0571-z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207039"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12739"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20128"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12799"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2011.06.986"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12149"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12149"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.167272"},{"issue":"1","key":"e_1_2_9_27_1","first-page":"21","article-title":"Update on acne scar treatment","volume":"102","author":"Soliman YS","year":"2018","journal-title":"Cutis"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.07.003"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1457-3"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7701020"},{"issue":"1","key":"e_1_2_9_31_1","first-page":"47","article-title":"Concerns and awareness of acne patients about isotretinoin in Qassim region of Saudi Arabia","volume":"4","author":"Al\u2010Harbi M","year":"2010","journal-title":"Int J Health Sci (Qassim)"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13669"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12768"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12885"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12402"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:00:30Z","timestamp":1692874830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,10]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/jocd.14316"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14316","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,10]]},"assertion":[{"value":"2020-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}