{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:31:12Z","timestamp":1762353072954,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>There are many endogenous and exogenous factors that cause acne formation. This study aimed to determine whether the acne severity in patients with various age ranges is associated with serum insulin\u2010like growth factor, insulin, and glucose and to identify how much they affect the acne severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this case\u2010control prospective study, 44 patients with\u00a0acne vulgaris\u00a0and 44 age\u2010 and gender\u2010matched control subjects without\u00a0acne\u00a0were evaluated. Patients and the control group were divided into two age\u2010groups as adolescence and post\u2010adolescence. According to the Global Acne Scoring System (GASS) of the acne group, the acne score grades between 0 and 44 were calculated. The correlations between the IGF\u20101, insulin, glucose levels, and acne grades were calculated in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our study, the acne scores and serum IGF\u20101\u00a0levels were found to be significantly higher in patients under the age of 21 than patients over the age of 21. There was a statistically significant difference in acne score between the two groups. However, there was no statistically significant difference between the serum IGF\u20101, insulin, and glucose levels of the acne group and the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, it has been revealed that IGF\u20101 is effective at the pathogenesis of acne in adolescence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14327","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T06:29:05Z","timestamp":1625207345000},"page":"1292-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of serum insulin\u2010like growth factor\u20101, insulin, glucose levels in patients with adolescent and post\u2010adolescent acne"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3834-1858","authenticated-orcid":false,"given":"Yesim","family":"Akpinar Kara","sequence":"first","affiliation":[{"name":"Department of Dermatology Koru Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10375.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1995.tb00057.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0099-z"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.3.333"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.110753"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd917"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00924.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14629-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"issue":"3","key":"e_1_2_10_12_1","article-title":"Committee on Practice and Ambulatory Medicine. 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