{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:38:23Z","timestamp":1779233903612,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photodynamic therapy (PDT) is considered an effective treatment for acne vulgaris. A significant drawback\u00a0is pain during illumination. Daylight PDT (DL\u2010PDT) is more tolerable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess and compare the efficacy and tolerability of DL\u2010PDT and C\u2010PDT for acne vulgaris through a prospective split\u2010face trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Fifteen patients underwent 4 treatment sessions at 3\u2010week intervals. First, 5\u2010aminolevulinic acid (ALA) was applied to the entire face, after which the face was divided into 2\u00a0symmetrical areas: The right side was exposed to sunlight, and the left half was illuminated with red light. Photographs were obtained and\u00a0evaluated by two dermatologists blinded to the study protocol. The patients reported side effects and downtime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant decrease in the number and percent change of inflammatory and non\u2010inflammatory lesions on both sides. Adverse effects were markedly decreased on the DL\u2010PDT side compared to the C\u2010PDT side (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). The average downtime duration was longer for the C\u2010PDT side (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DL\u2010PDT was at least as effective as C\u2010PDT with fewer adverse effects and a shorter downtime duration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14359","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T14:34:06Z","timestamp":1627828446000},"page":"3924-3930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A split\u2010face clinical trial of conventional red\u2010light photodynamic therapy versus daylight photodynamic therapy for acne vulgaris"],"prefix":"10.1111","volume":"20","author":[{"given":"Evgenia","family":"Slutsky\u2010Bank","sequence":"first","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine 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