{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:21:21Z","timestamp":1788970881317,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n Scalp seborrheic dermatitis (SD) is a chronic, relapsing, and inflammatory scalp disease. Studies indicate a global bacterial and fungal microbiota shift of scalp SD, as compared to healthy scalp. Ketoconazole and selenium disulfide (SeS\n 2<\/jats:sub>\n ) improve clinical signs and symptoms in both scalp dandruff and SD.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n The main objective of this study was to investigate the changes in the scalp microbiota diversity and counts in subjects with scalp SD during a two\u2010phase treatment period.<\/jats:p>\n <\/jats:sec>\n \n Material and methods<\/jats:title>\n \n The scalp microbiota and clinical efficacy were investigated in 68 subjects with mild\u2010to\u2010moderate scalp SD after an initial one\u2010month treatment with 2% ketoconazole, and after a 2\u2010month maintenance phase, either with a 1% SeS\n 2<\/jats:sub>\n \u2010based shampoo or its vehicle.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty one subjects in the active and 37\u00a0subjects in the vehicle group participated. Ketoconazole provided an improvement of clinical symptoms (adherent (\u22121.75\n p<\/jats:italic>\n \u00a0<\u00a00.05), non\u2010adherent (\u22121.5,\n p<\/jats:italic>\n \u00a0<\u00a00.05)) flakes and erythema (scores 1.67\u20130.93,\n p<\/jats:italic>\n \u00a0<\u00a00.001), in an increased fungal diversity and in a significant (\n p<\/jats:italic>\n \u00a0<\u00a00.005) decrease of\n Malassezia<\/jats:italic>\n spp. SeS\n 2<\/jats:sub>\n provided an additional clinical improvement (\u22120.8;\n p<\/jats:italic>\n \u00a0=\u00a00.0002 and \u22120.7;\n p<\/jats:italic>\n \u00a0=\u00a00.0081 for adherent and non\u2010adherent flakes, respectively, at Day 84) compared to the vehicle associated with a low\n Malassezia<\/jats:italic>\n spp. count and an additional significant (\n p<\/jats:italic>\n \u00a0<\u00a00.001) decrease of the\n Staphylococcus<\/jats:italic>\n spp. level.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Selenium disulfide provides an additional benefit on the scalp microbiota and in clinical symptoms of SD and dandruff after treatment with ketoconazole. The results confirm the role of\n Staphylococcus<\/jats:italic>\n spp. in scalp SD and open possible perspectives for preventing relapses.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.14362","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T15:20:22Z","timestamp":1629472822000},"page":"2215-2225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Continuous clinical improvement of mild\u2010to\u2010moderate seborrheic dermatitis and rebalancing of the scalp microbiome using a selenium disulfide\u2013based shampoo after an initial treatment with ketoconazole"],"prefix":"10.1111","volume":"21","author":[{"given":"Philippe","family":"Massiot","sequence":"first","affiliation":[{"name":"L\u2019Or\u00e9al Research & Innovation Saint\u2010Ouen 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