{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:13:20Z","timestamp":1779261200275,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne is one of the most common skin diseases in the adolescent period. Bisphenol A (BPA) is the most frequently observed endocrine\u2010disrupting chemicals that we are exposed to in daily life. BPA can affect acne pathogenesis with similar biological activity on androgenic receptors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate whether BPA levels play a role in the development and severity of acne in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one adults with acne and 50\u00a0healthy controls, whose ages varied between 18 and 25\u00a0years and applied to our dermatology outpatient clinic, were evaluated. A questionnaire containing dietary and lifestyle habits for BPA exposure was filled. BPA and BPA glucuronides were analyzed in the LC\u2010MS\/MS system in the first\u2010morning urine samples of the patients. Statistical significance was set at <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median levels of total BPA were significantly higher in the acne group compared with the control group (7.94 (4.69\u201320.32) vs. 5.62 (1.52\u201321.05) \u00b5g\/g creatinine, respectively; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.04)). The acne severity was positively associated with the BPA values (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.00 rs\u00a0=\u00a00.534). Higher BPA level was noticed in younger acne onset age (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.012 r\u00a0=\u00a0\u22120.349) When the inquiry questions were evaluated, no difference was found between the study groups regarding BPA exposure risk (<jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BPA could be a factor in acne development and its severity. Therefore, it may be beneficial to prevent BPA exposure and raise awareness in the adolescence and post\u2010adolescence period, in which industrial products such as junk food and plastic bottled water are used more frequently.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14364","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T13:15:15Z","timestamp":1628687715000},"page":"3573-3579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Could endocrine disruptors be a new player for acne pathogenesis? The effect of bisphenol A on the formation and severity of acne vulgaris: A prospective, case\u2010controlled study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-272X","authenticated-orcid":false,"given":"Hatice","family":"Kaya Ozden","sequence":"first","affiliation":[{"name":"Department of Dermatology Derince Training and Research Hospital Kocaeli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Serap","family":"Karadag","sequence":"additional","affiliation":[{"name":"Department of Dermatology Memorial Atasehir Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1584"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9371-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061439"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.871517"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_736_16"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2019-0034"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2011.05.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-014-4015-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.11.2839"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.10.010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(98)00114-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000003031"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.02.022"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.110753"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b00032"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b02135"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002701"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10753"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/es300115a"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/0265203031000119061"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf800870b"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2012.0090"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2016.02.020"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14364","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:33:08Z","timestamp":1693204388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jocd.14364"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14364","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]},"assertion":[{"value":"2021-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}