{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T23:44:48Z","timestamp":1783813488267,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Adipose\u2010derived stem cells (ASCs) have recently gained researchers\u2019 interest as a solution to various diseases and conditions, including hypertrophic scar. This literature review aims to elucidate ASCs as a potential solution to alleviate hypertrophic scar in human subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search was done in databases which includes PubMed, MEDLINE, and ProQuest using terms \u2018adipose derived stem cells\u2019, \u2018adipose cells\u2019, \u2018fat graft\u2019, \u2018fat grafting\u2019, \u2018autologous fat graft\u2019, \u2018fat injection\u2019, \u2018lipofilling\u2019, \u2018scar management\u2019, \u2018scar treatment\u2019, \u2018burn scar\u2019, and \u2018wound management\u2019. The included articles which were published during year 2000\u2010November 2020 must describe the use of ASCs or fat grafting or lipofilling as an attempt to alleviate hypertrophic scar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Remarks<\/jats:title><jats:p>Clinically, ASCs improve hypertrophic scars in terms of scar color, elasticity, texture, thickness, and size. Histologically, ASCs promotes healthy tissue regeneration, reduction in fibroblasts, and reorganisation of collagen, resembling those of normal skin. In terms of molecular aspects, ASCs alleviates hypertrophic scars through direct differentiation and paracrine mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adipose\u2010derived stem cells, emerge to be a potential solution for alleviating hypertrophic scar, as demonstrated in various studies. However, there has been no studies conducted in human subjects to investigate the effect of ASCs on hypertrophic scar.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14385","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T19:25:22Z","timestamp":1633807522000},"page":"1913-1919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A critical review on the potential role of adipose\u2010derived stem cells for future treatment of hypertrophic scars"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2763-310X","authenticated-orcid":false,"given":"Karina Teja","family":"Putri","sequence":"first","affiliation":[{"name":"Undergraduate Study Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-4309","authenticated-orcid":false,"given":"Theddeus Octavianus Hari","family":"Prasetyono","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Department of Surgery Cipto Mangunkusumo Hospital\/Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)31406\u20104"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000571"},{"key":"e_1_2_11_4_1","volume-title":"Burns","author":"World Health Organization","year":"2018"},{"key":"e_1_2_11_5_1","unstructured":"United Nations (2004) review and appraisal of the progress made in achieving the goals and objectives of the programme of action of the international conference on population and development the 2004 report. 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