{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:21:03Z","timestamp":1772601663024,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with connective tissue disease (CTD) often suffer from facial cutaneous defects and resultant facial asymmetry. Unfortunately, these issues have been known to be difficult\u2010to\u2010treat, and concern exists regarding the use of cosmetic procedures in this patient population due to the theoretical risk of disease flare\u2010up or reactivation. Injectable poly\u2010L\u2010lactic acid (PLLA) is one type of filler that has been used to treat skin atrophy in patients with morphea and lupus erythematous panniculitis. However, overall, there is a dearth in literature regarding the safety and efficacy of PLLA filler in patients with CTDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This case series intends to evaluate the safety and efficacy of PLLA filler in treating facial atrophy in patients with CTDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Three patients underwent various treatment courses involving the use of PLLA filler to treat facial atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two patients demonstrated significant improvement in facial atrophy following their treatment course. No patient experienced reactivation or exacerbation of their CTD following PLLA injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PLLA filler appears to have good viability as a safe and potentially effective treatment for facial atrophy in patients with CTDs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14422","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T20:54:25Z","timestamp":1630356865000},"page":"3462-3466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel use of poly\u2010L\u2010lactic acid filler for the treatment of facial cutaneous atrophy in patients with connective tissue disease"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8114-5628","authenticated-orcid":false,"given":"Jarod John","family":"Pamatmat","sequence":"first","affiliation":[{"name":"Department of Dermatology University of 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W.","family":"Goff","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001148"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.07.012"},{"key":"e_1_2_10_4_1","first-page":"295","article-title":"Dermal fillers in aesthetics: an overview of adverse events and treatment approaches","volume":"6","author":"Funt D","year":"2013","journal-title":"Clin Cosmet Investig 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