{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:59:17Z","timestamp":1778540357341,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Basal cell carcinoma (BCC) followed by squamous cell carcinoma (SCC) are the most common non\u2010melanoma skin cancer (NMSC). SOX2 is a transcription factor that acts on various phases of embryonic development and its overexpression in many tumors has been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This work aimed to evaluate the possible role of SOX2 in pathogenesis of non\u2010melanoma skin cancer through its immunohistochemical assessment in BCC and SCC compared to normal skin and correlating its expression with the established prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The investigated cases were 24 BCC, 21 SCC, and 26 normal skin specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SOX2 was not expressed in normal skin, but it was upregulated in SCC (85.7%) and BCC (66.7%), with a significant difference between malignant cases and normal skin (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). However, SOX2 expression did not differ between SCC and BCC. SOX2 expression was associated with large\u2010sized tumors in all malignant cases (BCC plus SCC) (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.02) and in SCC (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.043) alone together with its liability to be expressed in advanced stage in SCC (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.063).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SOX2 was over\u2010expressed in cutaneous SCC and BCC without a significant difference. SOX2\u00a0may enhance progression of NMSC manifested by its association with large tumor size and advanced stage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14433","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T18:22:22Z","timestamp":1631125342000},"page":"2623-2628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immunohistochemical expression of SOX2 in non\u2010melanoma skin cancer"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-2937","authenticated-orcid":false,"given":"Asmaa Gaber","family":"Abdou","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine Menoufia University  Shebein Elkom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal Farid","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Menoufia University  Shebein Elkom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar","family":"Gafar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andology and STDs Faculty of Medicine Menoufia University  Shebein Elkom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza Gaber Antar","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andology and STDs Faculty of Medicine Menoufia University  Shebein Elkom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-46227-7_6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0165-y"},{"key":"e_1_2_9_4_1","first-page":"83","volume-title":"Malignant Skin Tumors","author":"Mokhtar N","year":"2007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm059"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2014-0317"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.11.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0445-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.08.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.03.004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00242-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-019-00673-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5511"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"1617","article-title":"SOX2 knockdown inhibits the migration and invasion of basal cell carcinoma cells by targeting the SRPK1\u2010mediated PI3K\/AKT signaling pathway","volume":"17","author":"Li ZR","year":"2019","journal-title":"Oncol Lett"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_387_18"},{"issue":"1","key":"e_1_2_9_17_1","first-page":"136","article-title":"Histological grading of oral cancer: a comparison of different systems and their relation to lymph node metastasis","volume":"2","author":"Doshi NP","year":"2011","journal-title":"Natl J Commun Med"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10492"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800174"},{"issue":"5","key":"e_1_2_9_20_1","first-page":"2379","article-title":"SOX expression in non\u2010melanoma skin cancer","volume":"36","author":"Ornat M","year":"2016","journal-title":"Anticancer Res"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2016.00046"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.21608\/adjalexu.2019.63566"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2018-0348"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.540"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.168"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2017-204815"},{"issue":"1","key":"e_1_2_9_27_1","first-page":"28","article-title":"The expression profile of Oct4 and SOX2 in the carcinogenesis of oral mucosa","volume":"7","author":"Qiao B","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20714"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v6.i3.305"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e5e024"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.05.017"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10525"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11344"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/2468-838X.196089"},{"issue":"12","key":"e_1_2_9_36_1","first-page":"5010","article-title":"Prognostic significance of SOX2 in head and neck cancer: a meta\u2010analysis","volume":"7","author":"Dong Z","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12335"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:30:06Z","timestamp":1692829806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/jocd.14433"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14433","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,8]]},"assertion":[{"value":"2021-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}