{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:48Z","timestamp":1784557068379,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenetic alopecia (AGA) is a prevalent condition with a complex etiopathogenesis. Angiotensin\u2010converting enzyme (ACE) gene located on the chromosome 17q23 contains an insertion (I) and deletion (D) polymorphism in the intron 16. This gene polymorphism plays a role in multiple inflammatory disorders. However, there are no studies investigating its association with AGA susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this work, we aimed at exploring the association of <jats:italic>ACE<\/jats:italic> gene I\/D polymorphism in AGA susceptibility in a group of Egyptian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 100 AGA patients, and 100 apparently healthy controls. The <jats:italic>ACE<\/jats:italic> gene I\/D polymorphism was analyzed by polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DD, ID genotypes, and D allele showed higher frequent distribution among studied AGA patients than controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05 each). Positive family history and <jats:italic>ACE<\/jats:italic> gene I\/D polymorphism were considered AGA susceptibility predictors in both uni\u2010 and multivariable analyses [<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05 each (OR (95% CI)] on applying logistic regression analysis for risk factors prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the possible contribution of the suspected genetic polymorphism as a susceptibility indicator for AGA development in the examined group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14434","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T18:59:32Z","timestamp":1631213972000},"page":"2629-2634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between angiotensin\u2010converting enzyme gene insertion deletion polymorphism and androgenetic alopecia susceptibility among Egyptian patients: A preliminary case\u2010controlled study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-5787","authenticated-orcid":false,"given":"Amany Ibrahim","family":"Mustafa","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Benha University  Benha Egypt"},{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine October 6 University  Giza Governorate Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah Ezzat","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser Mostafa","family":"Gohary","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine 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