{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:28:56Z","timestamp":1776482936004,"version":"3.51.2"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperpigmentation is a common cosmetic concern that significantly impacts self\u2010esteem. A skincare regimen has been developed to improve the appearance, tone, texture, and luminosity of subjects with facial hyperpigmentation (Even Up<jats:sup>\u00ae<\/jats:sup> Hyperpigmentation Regimen; Colorescience, Inc., Carlsbad, CA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The objective of this open\u2010label trial was to assess the efficacy and tolerability of this regimen for treating facial hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Subjects with moderate\u2010to\u2010severe facial hyperpigmentation (<jats:italic>N\u00a0<\/jats:italic>=\u00a033) were randomized to those not using prescription, advanced or physician\u2010dispensed skin care products (Group A, <jats:italic>n<\/jats:italic>\u00a0=\u00a023) and those currently using prescription, advanced or physician\u2010dispensed skincare products for facial hyperpigmentation (Group B, <jats:italic>n<\/jats:italic>\u00a0=\u00a010). Both groups were provided three skincare products comprising the hyperpigmentation regimen and instructions for use. Subjects were evaluated at baseline and Weeks 2, 4, 8 and 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall median (range) baseline MASI score at baseline was 9.0 (2, 31), decreasing by 0.0 (\u22127, 0) points at Week 2 (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.002), 0.6 (\u22128, 0) points at Week 4 (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001), 1.5 (\u221216, 0) points by Week 8 (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001) and 2.4 (\u221220, 0) points at Week 12 (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001). At Week 12, the overall median improvement in MASI score was 26% and higher for Group B (32% vs. 22%). By Week 2, subjects reported lighter, less noticeable brown spots (76%), brighter, more luminous skin (88%), more even skin tone (67%), and healthier look and feel (85%). Improvements continued throughout the study. No adverse events were observed or reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This regimen addresses facial hyperpigmentation and protects skin against the damaging effects of ultraviolet and high energy visible light (HEV). It is safe to use on all skin types and tones.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14447","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T06:38:23Z","timestamp":1634798303000},"page":"2497-2507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Open\u2010Label Study Assessing the Efficacy and Tolerability of a Skincare Regimen in Subjects of Different Ethnicities with Moderate\u2010to\u2010Severe Hyperpigmentation"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-5090","authenticated-orcid":false,"given":"Kimberly","family":"Wenner","sequence":"first","affiliation":[{"name":"Cascade Eye &amp; Skin Centers  University Place WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany","family":"Ramberg","sequence":"additional","affiliation":[{"name":"Cascade Eye &amp; Skin Centers  University Place WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-020-00288-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12877"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0333-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S275783"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317700486"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02267.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.4887"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00384.x"},{"key":"e_1_2_10_10_1","first-page":"19","article-title":"Racial differences in clinical characteristics, perceptions and behaviors, and psychosocial impact of adult female acne","volume":"7","author":"Callender VD","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_11_1","first-page":"20","article-title":"Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color","volume":"3","author":"Davis EC","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S245043"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536930-000000000-00000"},{"key":"e_1_2_10_14_1","first-page":"471","article-title":"Facial primer provides immediate and long\u2010term improvements in mild\u2010to\u2010moderate facial hyperpigmentation and fine lines associated with photoaging","volume":"8","author":"Roberts WE","year":"2015","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13803"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690060057005"},{"key":"e_1_2_10_18_1","first-page":"592","article-title":"Use of hydroquinone as a bleaching cream","volume":"27","author":"Yi K","year":"1993","journal-title":"Ann Pharmacother"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00499.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202063260603"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680040067005"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305203282002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb03169.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1994.tb01790.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70030-J"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00144.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.169122"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb05110.x"},{"key":"e_1_2_10_29_1","first-page":"11","article-title":"Exogenous ochronosis from hydroquinone bleaching cream","volume":"62","author":"Fisher AA","year":"1998","journal-title":"Cutis"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2020.197"},{"key":"e_1_2_10_31_1","first-page":"51146","article-title":"Skin bleaching drug products for over\u2010the\u2010counter human use; 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