{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:59:13Z","timestamp":1791489553561,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Problematic toenails caused by various diseases that are infected by various bacteria are discolored or deformed if left unattended for a long time are gradually increasing in modern society. Accordingly, the present study examines the anti\u2010bacterial effects of LCN products, focused on\n Pseudomonas aeruginosa<\/jats:italic>\n and\n Trichophyton rubrum<\/jats:italic>\n , which can appear in problematic toenail symptoms. After the treatment, a significant anti\u2010bacterial effect occurring on problematic toenails when a product containing silver ion (Ag\n +<\/jats:sup>\n ) will be analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The anti\u2010bacterial activity of LCN functional gel products in anti\u2010fungal and\/or anti\u2010bacterial potency was confirmed by the paper disk method against two strains (\n Pseudomonas aeruginosa<\/jats:italic>\n and\n Trichophyton rubum<\/jats:italic>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n From July 2019 to October 2019, 30\u00a0men and women in their 20s and 50s who needed to manage problematic toenails in Wonju city, Gangwon\u2010do, Republic of Korea, were asked to use LCN products once every two weeks. After 4\u00a0months, changes in the managed toenails were observed. Both products showed very good anti\u2010microbial activity against,\n Trichophyton rubum<\/jats:italic>\n but a very weak one against\n Pseudomonas aeruginosa<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n As a result of this study, although there was a difference between individuals, the feet treated with LCN products showed effective anti\u2010bacterial activity against topical anti\u2010bacterial effects.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.14451","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T09:49:10Z","timestamp":1664099350000},"page":"6005-6009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010bacterial effects of functional cosmetics containing silver ions (Ag\n +<\/sup>\n ) on problematic toenails in Republic of Korea"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-7580","authenticated-orcid":false,"given":"Soo Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Beauty Arts Care, Department of Beauty Arts Care, Graduate School Dongguk University Seoul Republic of KOREA"},{"name":"Nail Bam Co. Wonju Republic of KOREA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Han","family":"Kwon","sequence":"additional","affiliation":[{"name":"College of General Education Kookmin University Seoul Republic of KOREA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3074"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3143\/geriatrics.53.123"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-017-0553-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3917\/spub.194.0507"},{"key":"e_1_2_9_6_1","article-title":"Evidence for current recommendations concerning the management of foot health for people with chronic long\u2010term conditions: a systematic review","volume":"22","author":"Edwards K","year":"2017","journal-title":"J Foot Ankle Res"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.16.00116"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000696"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13389"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153521"},{"key":"e_1_2_9_11_1","first-page":"1712","article-title":"Athlete's foot","volume":"20","author":"Crawford F","year":"2009","journal-title":"BMJ Clin Evid"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.1260"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/dtb.2002.40753"},{"key":"e_1_2_9_14_1","first-page":"680163","article-title":"New concepts in median nail dystrophy, onychomycosis, and hand, foot, and mouth disease nail pathology","volume":"26","author":"Hoy NY","year":"2012","journal-title":"ISRN Dermatol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.062"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417724439"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.12.009"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.12.019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1872213X13666191026090713"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.12.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201701503"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S191340"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-017-1846-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010166"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.97B5.33336"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1904.04032"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:35:16Z","timestamp":1791488116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,25]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/jocd.14451"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14451","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,25]]},"assertion":[{"value":"2021-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}