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Despite the recent progress in the treatment of acne vulgaris, the necessity for discovering more effective solutions has motivated many lines of research on natural and medicinal plants. The Traditional Persian Medicine (TPM) introduced some plants and remedies for acne treatment. Given the universal welcome for herbal medicine, this review was performed to formally assess the evidence for herbal medicines for acne vulgaris in TPM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medicinal plants used in this study for treating acne vulgaris were selected based on common references to the plants in five famous textbooks of TPM from different time periods. Then, the anti\u2010inflammatory and anti\u2010microbial effects of these medicinal plants were investigated according to the recent literature available in five electronic databases including Scopus, Web of Sciences, PubMed, Google Scholar, and Science Direct.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one herbs were commonly references in traditional TPM texts as helpful for topical treatment of acne vulgaris. The data collected from the electronic databases demonstrated most of these plants (eg, <jats:italic>Astragalus sarcocolla<\/jats:italic>, <jats:italic>Ficus carica<\/jats:italic>, and <jats:italic>Hordeum vulgare)<\/jats:italic> have both anti\u2010inflammatory and anti\u2010microbial mechanisms, which may assist to treat acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This scoping review demonstrated many medicinal plants recommended by TPM books have therapeutic potential for acne vulgaris via multiple mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14464","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T20:40:30Z","timestamp":1632688830000},"page":"2338-2348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mechanistic support of traditional Persian medicine for the treatment of acne vulgaris: A scoping 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