{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:42:42Z","timestamp":1761986562598,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Chronic spontaneous urticaria (CSU) is defined as recurrent attacks of urticaria present for more than six weeks. The monoclonal anti\u2010immunoglobulin E antibody, omalizumab, was approved for the treatment of CSU in patients who remain refractory to H1\u2010antihistamines. Biologic agents are shown not to increase the risk of COVID\u201019 infection in different studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In the present study, we aimed to determine the prevalance of COVID\u201019 infection in relation to the age, gender, presence of other comorbidities, and treatment given for CSU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a descriptive cross\u2010sectional study of 233 patients diagnosed with CSU in a tertiary referral hospital. Demographical data, treatment given for CSU, the presence of COVID\u201019\u2010related symptoms, history of close contact to a person with COVID\u201019 and COVID\u201019 real\u2010time polymerase chain reaction (RT\u2010PCR) results were determined via a telephone survey and checked from medical data records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred sixty patients were female; whereas 73 were male. The mean age was 44.76. Out of 233 patients with chronic urticaria, 125\u00a0had symptoms related to COVID\u201019 infection. RT\u2010PCR testing for COVID\u201019 was performed in 156 patients. Of 156 patients with COVID\u201019 RT\u2010PCR test, RT\u2010PCR result was positive in 15 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No statistically significant relationship was found between COVID\u201019 RT\u2010PCR positivity and the type of treatment administered for chronic urticaria when the patients are divided into omalizumab \u00b1 oral antihistamines and only oral antihistamines treatment groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.150). Omalizumab seems to be safe in the era of COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14484","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T11:29:35Z","timestamp":1633346975000},"page":"3369-3375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of COVID\u201019 on patients with chronic spontaneous urticaria treated with omalizumab and antihistamines: A cross\u2010sectional, comparative study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8296-4836","authenticated-orcid":false,"given":"Ecem","family":"Bostan","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fethi","family":"Zaid","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysen","family":"Karaduman","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duygu","family":"Gulseren","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basak","family":"Yalici\u2010Armagan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Hacettepe 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