{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:24:26Z","timestamp":1780374266143,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although the COVID\u201019 vaccination is deemed safe, exact incidence and nature if adverse effects, particularly dermatological ones, are still unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the demographic, clinical, morphological characteristics, outcomes, and timing of development of herpes zoster to the various COVID\u201019 vaccines. And to identify on whether COVID\u201019 vaccine has temporal relationship between development of herpes zoster (HZ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have performed a systemic review of articles from PubMed and Embase using MeSH and keywords like\u00a0\u201cShingles,\u201d \u201cHerpes zoster,\u201d \u201cVaricella zoster,\u201d \u201cCOVID\u201019,\u201d \u201cVaccine,\u201d \u201cSARS\u2010CoV\u20102.\u201d No filters including country of publication, language, type of articles were applied. Individual case report references were filtered for any pertinent cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 54 cases consisting of 27\u00a0male and 27 female patients have been reported. There were cases with known risk factors for herpes zoster, which included age more than 50\u00a0years (<jats:italic>n<\/jats:italic>\u00a0=\u00a036), immunological disorders (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), chronic disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a025), metabolic disorder (<jats:italic>n<\/jats:italic>\u00a0=\u00a013), malignancy (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), and psychiatric disorder (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). The mean (SD) period between development of herpes zoster and COVID\u201019 vaccination was 7.64 (6.92) days. Majority of the cases were from the high\u2010income and\/or middle\u2010income countries. 86.27% of the cases of HZ were reported due to mRNA vaccine. Thirty\u2010six patients 36\/45 (80%) developed herpes zoster following the priming dose of COVID\u201019 vaccine among those who received mRNA vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We could not establish definite link but there may be possible association between COVID\u201019 vaccine and shingles. Large\u2010scale studies may help to understand the cause\u2010effect relationship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14521","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T12:37:50Z","timestamp":1635683870000},"page":"3350-3361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Can SARS\u2010CoV\u20102 vaccine increase the risk of reactivation of Varicella zoster? 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