{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:16:20Z","timestamp":1753521380767,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperhidrosis is responsible for various causes. The increased reactive oxygen radical production with insufficient antioxidant mechanism capacity may play a role in the etiopathogenesis of hyperhidrosis. It is probable to gather data about oxidative stress by detecting plasma thiol\/disulfide ratio.<\/jats:p><jats:p>The aim of this study was to determine whether thiol\u2010disulfide balance changes in patients with hyperhidrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The files of patients who were diagnosed with hyperhidrosis in the dermatology outpatient clinic between 2015 and 2018 and whose native thiol, total thiol, and disulfide values were examined for any reason were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010three patients were included in the study. 33 of the patients with hyperhidrosis were primary.<\/jats:p><jats:p>Mean age; for primary hyperhidrosis patients (PHH)\u00a0=\u00a026.36\u00a0\u00b1\u00a07.61, primary hyperhidrosis (PHH) control group\u00a0=\u00a027.16\u00a0\u00b1\u00a07.94; secondary hyperhidrosis (SHH) patients\u00a0=\u00a047.88\u00a0\u00b1\u00a012.29, SHH control (45.40\u00a0\u00b1\u00a012.02). The native thiol values of PHH (469.93\u00a0\u00b1\u00a056.82\u00a0\u03bcmol\/L) were higher than SHH (440.64\u00a0\u00b1\u00a062.72) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.024).<\/jats:p><jats:p>However, as a result of thiol\u2010disulfide comparison between hyperhidrosis patients (PHH and SHH) and control groups, disulfide levels increased (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). In the PHH group, total thiol was measured as 512\u00a0\u00b1\u00a054.84\u00a0\u03bcmol\/L, and SHH was measured as 484.11\u00a0\u00b1\u00a058.9\u00a0\u03bcmol\/L, (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.074).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum thiol levels in SHH increased more than PHH. As a result of thiol\u2010disulfide comparison between hyperhidrosis patients and control groups, the balance shifted in favor of disulfide and oxidative side.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14533","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T18:30:00Z","timestamp":1634754600000},"page":"3031-3037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Can thiol\u2010disulfide balance be an indicator of oxidative stress for hyperhidrosis?"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-1796","authenticated-orcid":false,"given":"Ay\u015fe","family":"Akba\u015f","sequence":"first","affiliation":[{"name":"Ankara City Hospital, Dermatology  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-2675","authenticated-orcid":false,"given":"Fadime","family":"K\u0131l\u0131n\u00e7","sequence":"additional","affiliation":[{"name":"Ankara City Hospital, Dermatology  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"168","article-title":"The etiology, diagnosis and management of hyperhidrosis: a comprehensive review. 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