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The condition is primarily mediated by 5\u2010alpha\u2010reductase and dihydrotestosterone (DHT) which causes hair follicles to undergo miniaturization and shortening of successive anagen cycles. Although a variety of medical, surgical, light\u2010based and nutraceutical treatment options are available to slow or reverse the progression of AGA, it can be challenging to select appropriate therapies for this chronic condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To highlight treatment options for androgenetic alopecia taking into consideration the efficacy, side effect profiles, practicality of treatment (compliance), and costs to help clinicians offer ethically appropriate treatment regimens to their patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A literature search was conducted using electronic databases (Medline, PubMed, Embase, CINAHL, EBSCO) and textbooks, in addition to the authors' and other practitioners' clinical experiences in treating androgenetic alopecia, and the findings are presented here.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although topical minoxidil, oral finasteride, and low\u2010level light therapy are the only FDA\u2010approved therapies to treat AGA, they are just a fraction of the treatment options available, including other oral and topical modalities, hormonal therapies, nutraceuticals, PRP and exosome treatments, and hair transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Androgenetic alopecia therapy remains challenging as treatment selection involves ethical, evidence\u2010based decision\u2010making and consideration of each individual patient's needs, compliance, budget, extent of hair loss, and aesthetic goals, independent of potential financial benefits to the practitioners.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14537","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T10:59:27Z","timestamp":1636196367000},"page":"3759-3781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":386,"title":["Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-7932","authenticated-orcid":false,"given":"Mark S.","family":"Nestor","sequence":"first","affiliation":[{"name":"Center for Clinical and Cosmetic Research Aventura Florida USA"},{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miami Florida USA"},{"name":"Department of Surgery Division of Plastic Surgery University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glynis","family":"Ablon","sequence":"additional","affiliation":[{"name":"Ablon Skin Institute &amp; Research Center Manhattan Beach California USA"},{"name":"Department of Dermatology University of California Los Angeles (UCLA) Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Gade","sequence":"additional","affiliation":[{"name":"Center for Clinical and Cosmetic Research Aventura Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Clinical and Cosmetic Research Aventura Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Center for Clinical and Cosmetic Research Aventura Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"e_1_2_17_2_1","unstructured":"Giornale Italiano di Dermatologia e Venereologia 2014 February;149(1):15\u201024.https:\/\/www.minervamedica.it\/en\/journals\/dermatologia\u2010venereologia\/article.php?cod=R23Y2014N01A0015. 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