{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:02:12Z","timestamp":1773338532948,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris (AV) is an extraordinarily common skin condition.\u00a0The high prevalence of AV is linked to the exposure factors, as environmental pollutants and climatic factors, occupational, psychosocial, and lifestyle factors. The AhR plays a critical\u00a0part in environmental toxic action. The AhR expression and imbalance in the IL\u201036 &amp; 38 expression may have a role in inflammation and AV pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To detect possible links between environmental, inflammatory, and anti\u2010inflammatory factors in AV pathogenesis through measuring AhR, IL\u201036, and IL\u201038\u00a0mRNA gene expression levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Total of 100\u00a0subjects (70 AV patients and 30 apparently healthy control subjects) were tested for AhR, IL\u201036\u03b3, and IL\u201038\u00a0mRNA levels by quantitative real\u2010time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median levels of AhR and IL\u201036\u00a0mRNA gene expression were considerably greater, while that of IL\u201038 was essentially lower in AV than healthy subjects (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, 0.021 and 0.002, respectively). The AhR and IL\u201036\u00a0mRNA gene expression levels increased, while IL\u201038 decreased significantly with higher grades of severity (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, 0.001, and &lt;0.001, respectively). ROC curve showed that AhR mRNA gene expression level had the best AUC for diagnosis of AV, with better sensitivity and specificity than IL\u201036 and IL\u201038.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher levels of AhR, IL\u201036, and lower levels of IL\u201038\u00a0gene expression were significantly associated with AV patients and higher grades of severity. AhR had better diagnostic ability than IL\u201038 and IL\u201036.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14542","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T21:16:30Z","timestamp":1634937390000},"page":"3038-3045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Environmental, inflammatory, and anti\u2010inflammatory squad in acne vulgaris pathogenesis: AhR, IL\u201036, and IL\u201038"],"prefix":"10.1111","volume":"21","author":[{"given":"Fatma","family":"Mohamed El Esawy","sequence":"first","affiliation":[{"name":"Dermatology, Venereology and Andrology Faculty of Medicine Benha University  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzan","family":"Ali Mohammed","sequence":"additional","affiliation":[{"name":"Medical Biochemistry &amp;Molecular Biology Faculty of Medicine Benha University  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebtesam","family":"Nasar Zargon Nasar","sequence":"additional","affiliation":[{"name":"MBB Ch Faculty of Medicine Sirte University  Libya"},{"name":"Dermatology, Venereology and Andrology Department Ibn Sina Hospital  Sirte Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Hemdan Mostafa","sequence":"additional","affiliation":[{"name":"MBB Ch Faculty of Medicine Benha University  Egypt"},{"name":"Dermatology Department Benha Children Hospital  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2744-8975","authenticated-orcid":false,"given":"Doaa M.","family":"Elhabak","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Faculty of Medicine Benha University  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","first-page":"33","article-title":"An update on the presence of psychiatric comorbidities in acne patients: Part 1. 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