{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T09:28:21Z","timestamp":1748424501044},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although dysbiosis and the role of the microbiome in the pathogenesis of inflammatory skin diseases have been intensively investigated, fungal colonization or infection has received minimal attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To isolate and identify different fungal species namely <jats:italic>Candida<\/jats:italic>, <jats:italic>Dermatophytes<\/jats:italic>, <jats:italic>Malassezia<\/jats:italic>, and <jats:italic>Aspergillus<\/jats:italic> from plaque psoriasis patients, evaluate the association of IL\u201017A gene single nucleotide polymorphisms (SNPs) with psoriasis, and to reveal the relation between IL\u201017A gene SNPs and the fungal presence within the psoriatic plaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Fifty plaque psoriasis patients and fifty healthy age and sex volunteers as controls were enrolled in this study. From psoriatic plaques, mycological isolation was done by direct microscopic examination (10% KOH mount), culture onto the three sets of media then species identification by phenotypic procedures. Genomic DNA extraction and genotyping for IL\u201017A (rs10484879) SNPs using polymerase chain reaction and restriction fragment length polymorphism were also done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Psoriasis cases showed higher frequency of fungal growth 86% vs. 14% in controls; (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The frequency of IL\u201017A GA, AA, and total polymorphism (GA+AA) genotypes in psoriasis cases was significantly higher than in controls. There was non\u2010significant association between different IL\u201017A genotypes and fungal growth except <jats:italic>Aspergillus flavus<\/jats:italic>, which decreased gradually with GG, GA, and AA (37.5%, 20.8%, and 0%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Psoriasis cases are significantly associated with fungal growth, which may be a contributing factor in its pathogenesis. SNPs of IL\u201017A (rs10484879) G\/A gene led to increased susceptibility toward pathogenesis of psoriasis. Fungal growth and IL\u201017A GA+AA genotypes are suggested to be independent predictors of psoriasis susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14551","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T15:40:36Z","timestamp":1636213236000},"page":"3059-3067","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interleukin\u201017A gene single nucleotide polymorphism and its relation to fungal growth in psoriatic patients: A preliminary study"],"prefix":"10.1111","volume":"21","author":[{"given":"Eman M. 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