{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:07:44Z","timestamp":1773018464667,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602784"],"award-info":[{"award-number":["81602784"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703149"],"award-info":[{"award-number":["81703149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974480"],"award-info":[{"award-number":["81974480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>No researches about the interaction among the risk factors for rosacea were conducted. Some studies prompted obesity and spicy food may have some common pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To clarify the relationship between body mass index (BMI) and rosacea, and explore the interaction between BMI and spicy food consumption in rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This hospital\u2010based case\u2010control study enrolled 1347 rosacea patients and 1290 healthy subjects. The demographic data and clinical data were collected. The association between BMI and rosacea, and the relative excess risk due to interaction of BMI and spicy food consumption was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No interaction was found between underweight, overweight\/obesity, and spicy food consumption with regard to the risk of rosacea, mild\u2010to\u2010moderate rosacea, papulopustular rosacea (PPR), or phymatous rosacea (PhR). And underweight and overweight\/obesity were not significant associated with rosacea, mild\u2010to\u2010moderate rosacea, PPR, or PhR (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). However, spicy food consumption was significantly interacted with underweight on the risk of erythematotelangiectatic rosacea (ETR), and with overweight\/obesity on the risk of severe rosacea. Underweight was associated with increased risk of ETR (adjusted odds ratio [aOR]\u00a0=\u00a01.91, 95% confidence interval [CI]: 1.21, 3.03) among spicy no users, but the association was attenuated into insignificant level when mixed with spicy food factor (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Among moderated spicy food consumers, overweight\/obesity was associated with decreased risk of severe rosacea (aOR\u00a0=\u00a00.70, 95% CI: 0.50, 0.98), but overweight\/obesity was insignificant associated with severe rosacea among spicy no users and heavy spicy food consumers (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Body weight status alone was not significantly associated with rosacea, but the interaction between body weight status and spicy food consumption is involved in the rosacea.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14556","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T15:38:35Z","timestamp":1635694715000},"page":"3068-3077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Interaction between body weight status and spicy food consumption on the risk of rosacea: A multi\u2010central, hospital\u2010based, case\u2010control study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-3447","authenticated-orcid":false,"given":"Ben","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine The Medicine School of Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhili","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital Central South University  Changsha China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province Central South University  Changsha China"},{"name":"Center for Molecular Medicine Xiangya Hospital Central South University  Changsha 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