{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:13:27Z","timestamp":1766870007683,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Skin exposure to tobacco smoke is closely related to skin aging. Ferroptosis is an iron\u2010dependent form of regulated cell death driven by the accumulation of lipid peroxides to levels sufficient to trigger cell death. However, few studies have examined ferroptosis in skin\u2010related diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study searched for differentially expressed genes by analyzing gene expression data downloaded from the Gene Expression Omnibus. Ferroptosis\u2010related genes were obtained by analyzing the FerrDb database. We also investigated the regulatory mechanism of ferroptosis\u2010related genes by enrichment analysis and constructing gene\u2010miRNA and gene\u2010transcription factor networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on these analyses, exposure to cigarette smoke can cause ferroptosis in female skin. Ferroptosis\u2010associated genes might be regulated by 17 miRNAs and 20 TFs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Finally, we found ferroptosis in the skin of women exposed to cigarette smoke, and the results provide an important theoretical basis for future research and anti\u2010aging treatment of skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14559","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T08:03:06Z","timestamp":1635321786000},"page":"3085-3094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cigarettes, a skin killer! 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