{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:19:36Z","timestamp":1788985176356,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy and safety of resveratrol combined with ablative fractional CO<jats:sub>2<\/jats:sub>\u00a0laser system (AFL) treating skin photoaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two\u00a0subjects were assigned to the treatment group (TG) or the control group (CG), respectively, applied test product (resveratrol essence) or control product twice daily for 6\u00a0months. Each subject was given an AFL treatment or no laser treatment on left or right side of the face randomly. Subjective evaluations by investigators and subjects themselves were conducted after treatment. Melanin index, erythema index, and cuticle moisture content were conducted at baseline and after treatments. Adverse events (AEs) were evaluated during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All subjects in TG achieved improvements of their photoaging signs compared to pre\u2010treatment both the laser side and the non\u2010laser side at 6\u00a0months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). On the laser side, TG produced a better improvement than CG at 6\u00a0months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). On the laser side, the difference values of MI in TG at the 2\u00a0months after enrollment (M2), M3, and M4 were more obvious than those in CG (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). On the non\u2010laser side, the difference values of MI in TG at M3, M4, M5, and M6 were more obvious than those of CG (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Subjects in TG were more likely to have tingling and had a faster subsidence of erythema mild edema, and pigmentation induced by AFL compared to CG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The resveratrol can improve photoaging alone and add an efficacy to the AFL treatment and subside the AEs induced by AFL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14569","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T15:21:15Z","timestamp":1635693675000},"page":"3880-3888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of Resveratrol combined with Ablative Fractional CO<sub>2<\/sub> laser system in the treatment of skin photoaging"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8243-335X","authenticated-orcid":false,"given":"Yi\u2010Mei","family":"Du","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University Shenyang China"},{"name":"NHC Key Laboratory of Immunodermatology (China Medical University) Shenyang China"},{"name":"Key Laboratory of Immunodermatology (China Medical University) Ministry of Education Shenyang China"},{"name":"National and Local Joint Engineering Research Center of Immunodermatological Theranostics Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University Shenyang China"},{"name":"NHC Key Laboratory of Immunodermatology (China Medical University) Shenyang China"},{"name":"Key Laboratory of Immunodermatology (China Medical 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Medical University) Shenyang China"},{"name":"Key Laboratory of Immunodermatology (China Medical University) Ministry of Education Shenyang China"},{"name":"National and Local Joint Engineering Research Center of Immunodermatological Theranostics Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University Shenyang China"},{"name":"NHC Key Laboratory of Immunodermatology (China Medical University) Shenyang China"},{"name":"Key Laboratory of Immunodermatology (China Medical University) Ministry of Education Shenyang China"},{"name":"National and Local Joint Engineering Research Center of Immunodermatological Theranostics Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Qun","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China 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