{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:13:37Z","timestamp":1778663617772,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773349"],"award-info":[{"award-number":["81773349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Port\u2010wine stain (PWS) is a congenital capillary malformation that often occurs on the face. Feasible and quantitative evaluation of facial port\u2010wine stain (FPWS) can significantly impact its clinical management and aid in future research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To develop and validate an easy\u2010to\u2010use scoring system for FPWS evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A facial port\u2010wine stain area and severity index (FSASI) scoring system was proposed. To determine the FSASI score, the face was divided into four regions: forehead, right malar, left malar, and perioral. The severity of FPWS in each region was evaluated by three factors: percentage of the area affected, lesion color, and thickness. To evaluate the intra\u2010 and inter\u2010rater reliability of FSASI, two separate FSASI assessments on 111\u00a0clinical pictures were conducted by each rater in a one\u2010week interval, and the results from 6 independent raters at different time points were compared. Validity of the FSASI scores was assessed by comparing it with physician global assessment (PGA) and traditional classification data. Validity of the area and color elements of FSASI was also determined. The changes in FSASI scores after vascular\u2010targeted photodynamic therapy (V\u2010PDT) were analyzed to evaluate the treatment effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The FSASI scoring system showed good intra\u2010 and inter\u2010rater reliability (ICC &gt;0.75, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and was found to be comparable to PGA scores (Spearman's r\u00a0=\u00a00.752\u20130.907, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and traditional classification data (Spearman's r\u00a0=\u00a00.426\u20130.662, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Efficacy analysis indicated that FSASI scores decreased after V\u2010PDT treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study demonstrated the reliability and validity of FSASI, which may be applied to assess the severity of FPWS and to evaluate treatment effects in clinical practice and research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14574","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T17:20:02Z","timestamp":1636219202000},"page":"2931-2938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A proposed scoring system for facial port\u2010wine stain evaluation: Facial port\u2010wine stain area and severity index"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-9613","authenticated-orcid":false,"given":"Jie","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Dermatology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Photomedicine Laboratory Institute of Precision Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiaohan","family":"Tuan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Photomedicine Laboratory Institute of Precision Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Photomedicine Laboratory Institute of Precision Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Photomedicine Laboratory Institute of Precision Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Photomedicine Laboratory Institute of Precision Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eray Yihui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Photomedicine Laboratory Institute of Precision Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Photomedicine Laboratory Institute of Precision Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Dermatology First Hospital Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4531-8632","authenticated-orcid":false,"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Photomedicine Laboratory Institute of Precision Medicine Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"2531","article-title":"Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People's Republic of China","volume":"8","author":"Shi W","year":"2014","journal-title":"Drug Des Devel 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