{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:39:02Z","timestamp":1779881942671,"version":"3.53.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Noncultured epidermal cell suspension (NCES) transplantation is a commonly used surgical treatment for resistant stable vitiligo. The combination of platelet\u2010rich plasma (PRP) with different therapeutic modalities for vitiligo yielded higher repigmentation response, probably due to platelet\u2010derived growth factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of PRP\u2010suspended NCES compared to NCES suspended in Ringer's lactate (RL) solution in the treatment of stable vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A prospective comparative study was conducted on 40 patients with stable vitiligo. They were divided into two equal groups: group A (treated with RL\u2010suspended NCES) and group B (treated with PRP\u2010suspended NCES). All patients were followed\u2010up for 6\u00a0months for assessment of their therapeutic response regarding clinical outcomes and immunohistochemical expression of HMB\u201045 in lesional skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients treated with PRP\u2010suspended NCES showed a significantly higher repigmentation response compared to those treated with RL\u2010suspended NCES at 1, 3, and 6\u00a0months after treatment (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.015, 0.023, 0.029, respectively). The expression of HMB\u201045\u00a0significantly increased in both groups after therapy, but without a significant difference between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The repigmentation response of NCES can be enhanced by suspending the melanocytes in autologous PRP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14576","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T19:35:20Z","timestamp":1635363320000},"page":"3102-3109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Non\u2010cultured epidermal cells suspended in either platelet\u2010rich plasma or ringer lactate for stable vitiligo: A prospective comparative study"],"prefix":"10.1111","volume":"21","author":[{"given":"Waleed","family":"Albalat","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8045-5547","authenticated-orcid":false,"given":"Rana","family":"Ehab","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-9672","authenticated-orcid":false,"given":"Manal","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0298-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.048"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"118","article-title":"Updates in surgical treatment of vitiligo","volume":"2","author":"Gamal 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intra\u2010operative injected platelet\u2010rich plasma therapyduring follicular unit extraction hair transplant: a prospective randomized study in forty patients","volume":"9","author":"Garg S","year":"2016","journal-title":"J CutanAesthet Surg"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.10.041"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12759"},{"key":"e_1_2_10_24_1","first-page":"66","article-title":"Treatment of vitiligo ondifficult\u2010to\u2010treat sites using autologous noncultured cellulargrafting","volume":"35","author":"Mulekar SV","year":"2009","journal-title":"Dermatol Surg"}],"container-title":["Journal of Cosmetic 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