{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:38:56Z","timestamp":1765888736996,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>In the last decades, attention to the role of lymphangiogenesis in psoriasis has been paid. Our study was conducted to evaluate podoplanin\u2010stained lymphatic vessels and the level of lymphangiogenesis in papular psoriatic lesions and psoriatic plaques and ascertain if podoplanin provides any additional prognostic information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Number of lymphatic vessels and total lymphatic vessel area were morphometrically analyzed in podoplanin\u2010stained sections, using anti\u2010D2\u201040, together with the immunohistochemical study of epidermal Ki\u201067 in psoriasis vulgaris (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) (papules\u00a0=\u00a07 and plaques\u00a0=\u00a013) and control skin specimens (<jats:italic>n<\/jats:italic>\u00a0=\u00a020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of lymphatic vessels and total lymphatic vessel area were higher in psoriasis cases compared with normal skin (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01 respectively). In psoriatic plaques, the number of lymphatic vessels, total lymphatic vessel area, and epidermal Ki\u201067 immunoreactivity were higher than in papular lesions (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008, and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Psoriasis vulgaris is found to be a lymphangiogenesis\u2010dependent disease, and the lymphatic vascular network is in remodeling and expanding process. Podoplanin may be implicated in the pathogenesis of psoriasis and could be used as a prognostic biomarker for disease severity and progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14580","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T10:09:24Z","timestamp":1635588564000},"page":"3110-3116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Morphometric study of lymphangiogenesis in different lesions of psoriasis vulgaris with correlation to disease activity"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-704X","authenticated-orcid":false,"given":"Nourhan","family":"Anis","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Andrology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Assaf","sequence":"additional","affiliation":[{"name":"Pathology Department Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagwa","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Andrology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Soliman","sequence":"additional","affiliation":[{"name":"Pathology Department\u2010 Medical Division National Research Center  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-8113","authenticated-orcid":false,"given":"Eman","family":"Salah","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Andrology Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1989.2"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-12270-6_1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.12.011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2014.10.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2012.00189.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20143210"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12681007"},{"issue":"2","key":"e_1_2_10_9_1","first-page":"118","article-title":"Podoplanin: an insight into its role in tumor invasion and metastasis","volume":"8","author":"Deepa AG","year":"2017","journal-title":"Oral Maxillofac Pathol J"},{"issue":"4","key":"e_1_2_10_10_1","first-page":"1141","article-title":"Podoplanin, novel 43 kDa membrane protein of glomerular epithelial cells, is down\u2010regulated in puromycin nephrosis","volume":"151","author":"Breiteneder\u2010Geleff S","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V9112013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690393"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62311-5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880543"},{"key":"e_1_2_10_15_1","first-page":"961","article-title":"Quantitative changes of the capillary bed in aging human skin","volume":"27","author":"V\u00fdbohov\u00e1 D","year":"2012","journal-title":"Histol Histopathol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00666038"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-64"},{"key":"e_1_2_10_18_1","first-page":"138","article-title":"Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER\u2010ICA) in breast cancer tissue","volume":"8","author":"Remmele W","year":"1987","journal-title":"Pathologe"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-015-0349-7"},{"issue":"5","key":"e_1_2_10_20_1","first-page":"461","article-title":"Microvascular changes in relation to inflammation and epidermal hyperplasia in chronic cutaneous lesions of psoriasis vulgaris","volume":"32","author":"V\u00fdbohov\u00e1 D","year":"2017","journal-title":"Histol Histopathol"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-201"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2964"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)80182-0"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08608.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08889.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.12.006"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217697385"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9406-1"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018422"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.1994.5810077.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200410-1398OC"},{"issue":"1","key":"e_1_2_10_32_1","first-page":"55","article-title":"Proliferative activity in basal cell carcinomas","volume":"44","author":"Florescu D","year":"2018","journal-title":"Curr Health Sci J"},{"issue":"1","key":"e_1_2_10_33_1","first-page":"735","article-title":"Differential expression of cyclin D1, Ki\u201067, pRb, and p53 in psoriatic skin lesions and normal skin","volume":"17","author":"Kim S","year":"2018","journal-title":"Mol Med Rep"},{"issue":"1","key":"e_1_2_10_34_1","first-page":"29","article-title":"Immunohistochemical expression of P53 and Ki\u201067 in different histopathological variants of basal cell carcinoma","volume":"6","author":"Esmaeili R","year":"2015","journal-title":"MEJC"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12060"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.61"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12830"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.11.010"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13711"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:24:24Z","timestamp":1692566664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,30]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jocd.14580"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14580","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2021,10,30]]},"assertion":[{"value":"2021-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}