{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:21:44Z","timestamp":1783570904798,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T00:00:00Z","timestamp":1635638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Monochromatic excimer light (MEL) is a safe and effective treatment for localized stable vitiligo. Previous reports of the combination of platelet\u2010rich plasma (PRP) with narrowband ultraviolet B (NB\u2010UVB) or excimer laser yielded conflicting results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This prospective, self\u2010controlled, randomized, comparative study aimed to assess whether the addition of PRP to MEL therapy would be of an additive benefit in the treatment for localized stable vitiligo.<\/jats:p><jats:p><jats:bold>Patients\/Methods<\/jats:bold> The current study included 36 patients with at least 2\u00a0more or less symmetrical patches of localized stable vitiligo (72 patches). For each patient, each of the 2 vitiligo patches was randomly assigned to receive either MEL therapy (twice weekly) with bi\u2010weekly intradermal PRP (group A) or MEL therapy alone (group B) for a maximum of 4\u00a0months or till complete repigmentation. The degree of repigmentation was categorized as absent (0%), poor (1\u201325%), moderate (26\u201350%), good (51\u201375%), or excellent (&gt;75%). Patients were asked about their level of satisfaction (not satisfied at all, partially satisfied, satisfied, or completely satisfied). Side effects were recorded, and follow\u2010up for 3\u00a0months was done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant difference was observed between the 2\u00a0groups regarding the degree of repigmentation, the patients\u2019 level of satisfaction, and the frequency of side effects (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.504, 0.490, and 0.912, respectively). At the end of the follow\u2010up period, recurrence was observed in only 3 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current study showed no statistically significant difference between using MEL alone or with intradermal PRP in the treatment for localized stable vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14582","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T12:27:51Z","timestamp":1635683271000},"page":"2826-2831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison between 308\u2010nm excimer light alone versus 308\u2010nm excimer light and platelet\u2010rich plasma in the treatment for localized vitiligo"],"prefix":"10.1111","volume":"21","author":[{"given":"Ahmed Elsaeed","family":"Elsaadany","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-6160","authenticated-orcid":false,"given":"Mohamed","family":"El\u2010Khalawany","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Rashad","family":"Elshahid","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Kamel","family":"Seddeik Abdel\u2010Hameed","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12949"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11008.x"},{"key":"e_1_2_7_4_1","first-page":"e15058","article-title":"Is targeted UVB as effective as excimer light phototherapy in treatment of vitiligo?","author":"Tabassum H","year":"2021","journal-title":"Dermatol Ther"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0218-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1572861"},{"issue":"8","key":"e_1_2_7_7_1","first-page":"28","article-title":"Progress in the use of platelet\u2010rich plasma in aesthetic and medical dermatology","volume":"13","author":"Lin M\u2010Y","year":"2020","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.09.021"},{"key":"e_1_2_7_9_1","unstructured":"LimH ShM LeeM. Clinical application of PRP in vitiligo: a pilot study. 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Clinical application of platelet\u2010rich plasma in vitiligo: a pilot study. Poster Presentation. Paper presented at: 21st International Pigment Cell Conference2011."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13215"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13524"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12619"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T21:24:29Z","timestamp":1692566669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,31]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jocd.14582"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14582","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,31]]},"assertion":[{"value":"2021-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}