{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:24:44Z","timestamp":1788020684455,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperpigmentation is a common concern of patients in dermatology clinics. Although there are many treatment options, lasers are considered a promising therapy for various hyperpigmentary conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to evaluate the efficacy of alexandrite 755\u2010nm picosecond and neodymium\u2010doped yttrium aluminum garnet (Nd:YAG) 1064\u2010nm picosecond lasers for the treatment of ultraviolet B (UVB)\u2010induced hyperpigmentation in Asians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A randomized, single\u2010blinded study was conducted. UVB\u2010induced hyperpigmentation was performed in three spots by narrowband UVB. After 2\u00a0weeks, these three spots were allocated into 755\u2010treated, 1064\u2010treated, and control sites. Patients received weekly laser treatments for five sessions. Follow\u2010ups were scheduled at 1 and 2\u00a0months after the last session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients attended the study. Overall, 755\u2010nm and 1064\u2010nm picosecond lasers showed a significant improvement in the mean lightness index (<jats:italic>L<\/jats:italic>*) compared to the control site, which started at Day\u00a049 and Day\u00a077, respectively. The mean <jats:italic>L<\/jats:italic>* of the 755\u2010nm\u2010treated site was also higher than that of the 1064\u2010nm\u2013treated site at Day\u00a0105 (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.001). Initially, the mean <jats:italic>L<\/jats:italic>*, physician's visual analog scale (VAS), and patient satisfaction with the 1064\u2010nm picosecond laser were better than those with the 755\u2010nm picosecond laser. Nevertheless, an inversion of the mean <jats:italic>L<\/jats:italic>* and VAS was noted at Day\u00a049, whereas the mean patient satisfaction was noted at Day\u00a077. In the subgroup analysis, a 755\u2010nm picosecond laser effectively treated Fitzpatrick skin types (FPTs) III and IV. However, the mean <jats:italic>L<\/jats:italic>* of the 1064\u2010nm picosecond laser was not significantly different from that of the control for FPT4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The alexandrite 755\u2010nm picosecond and Nd:YAG 1064\u2010nm picosecond lasers appear to be effective and safe modalities for treating UVB\u2010induced hyperpigmentation. With the setting employed in this study, the outcome after the 755\u2010nm picosecond laser treatment seemed superior to that of the 1064\u2010nm picosecond laser treatment, especially for FPT4.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14591","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T17:45:40Z","timestamp":1636825540000},"page":"1036-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A single\u2010blinded, randomized, controlled trial comparing efficacy between low\u2010fluence alexandrite 755\u2010nm picosecond laser and low\u2010fluence neodymium\u2010doped yttrium aluminum garnet (Nd:YAG) 1064\u2010nm picosecond laser for the treatment of ultraviolet B\u2010induced 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Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-5796","authenticated-orcid":false,"given":"Natthachat","family":"Jurairattanaporn","sequence":"additional","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok 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