{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:15:24Z","timestamp":1770977724574,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In mild psoriasis, topical agents remain the mainstay of treatment. However, the available treatments are not satisfactory for a significant proportion of patients in many terms such as efficacy and safety. Because of these deficits, augmentation of therapeutic effect seems desirable.<\/jats:p><\/jats:sec><jats:sec><jats:title>This study aims<\/jats:title><jats:p>To evaluate the efficacy of topical cyclosporine cream, delivered by fractional CO<jats:sub>2<\/jats:sub> laser vs the efficacy of topical clobetasol cream for the treatment of mild to moderate plaque psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Twenty\u2010two patients with chronic plaque psoriasis involving &lt;10% BSA were included in this study. They were randomly allocated into 2 groups. In Group A, patients were instructed to apply cyclosporine cream twice daily for 5 consecutive days per week immediately after fractional carbon dioxide laser session. While in Group B, clobetasol cream was applied twice daily for 5 consecutive days per week until complete clearance or for a maximum of 10\u00a0weeks.<\/jats:p><jats:p>The efficacy was objectively assisted clinically and by histopathology by using the scores and skin biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant improvement of erythema, plaque elevation, and scaling (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) with the use of topical cyclosporine cream delivered by the aid of fractional CO<jats:sub>2<\/jats:sub> laser, compared to base line. However, the improvement was more significant with topical clobetasol cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laser\u2010assisted delivery of topical cyclosporine can provide comparable clinical and pathological improvement to that of clobetasol in the psoriatic plaques. These findings were apparent in patients with less widespread disease. However, topical steroid showed more improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14595","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T06:04:36Z","timestamp":1637215476000},"page":"3362-3370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of the topical cyclosporine cream assisted by fractional carbon dioxide laser vs topical clobetasol cream for the treatment of plaque psoriasis: Randomized comparative study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-1450","authenticated-orcid":false,"given":"Yasser","family":"Helmy A.","sequence":"first","affiliation":[{"name":"Faculty of Medicine Al\u2010Azhar University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Hashem","family":"El batreek","sequence":"additional","affiliation":[{"name":"General authority for health insurance Egyptian Ministry of Health  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa Ahmed","family":"Abdel Fadeel","sequence":"additional","affiliation":[{"name":"Medical applications of laser National Institute of Laser Enhanced Sciences  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-6870","authenticated-orcid":false,"given":"Abeer Attia","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Medical applications of laser National Institute of Laser Enhanced Sciences  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-0629","authenticated-orcid":false,"given":"Nevien Ahmed","family":"Samy","sequence":"additional","affiliation":[{"name":"Medical applications of laser National Institute of Laser Enhanced Sciences  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00766-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.768"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218406"},{"issue":"1","key":"e_1_2_12_7_1","first-page":"52","article-title":"Excimer laser for psoriasis treatment: a case report and short review","volume":"20","author":"Ardeleanu V","year":"2020","journal-title":"Exp Ther Med"},{"issue":"27","key":"e_1_2_12_8_1","first-page":"1","article-title":"Ultraviolet phototherapy management of moderate\u2010to\u2010severe plaque psoriasis: an evidence\u2010based analysis","volume":"9","author":"Medical Advisory Secretariat","year":"2009","journal-title":"Ont Health Technol Assess Ser"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.09.021"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.008"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2017.046"},{"key":"e_1_2_12_12_1","first-page":"464","article-title":"Harmonization of thresholds of primary skin irritation from results of human repeated insult patch tests and laboratory animal skin irritation tests","volume":"40","author":"Tardiff RJ","year":"2003","journal-title":"J Appl Toxicol"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250839"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/247553031117a00403"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/247553031117a00403"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.12.004"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2009.0767"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36966-0"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119234"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12276"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.08.005"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.03992.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.0859"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.82"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2704"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.21608\/aimj.2020.30442.1232"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2318"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002195"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14306"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13633"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13425"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12895-020-00116-9"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001934"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14595","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T03:01:24Z","timestamp":1692500484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,17]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jocd.14595"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14595","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,17]]},"assertion":[{"value":"2021-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}