{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:12:31Z","timestamp":1785406351958,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is an acquired cutaneous depigmenting disease caused by a T helper (Th) 1\u2013cytotoxic T cells driven autoimmune attack against melanocytes, in which Th17 is also involved. Interleukin (IL)\u201038 belongs to the IL\u20101 family of cytokines and suppresses Th1 and Th17 activation. IL\u201038 protein and mRNA levels have been found to be elevated in various autoimmune disorders and correlated with disease severity and activity, including psoriasis, systemic sclerosis, rheumatoid arthritis, and atopic dermatitis. No previous studies have been performed to investigate the expression of IL\u201038 in patients with vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate IL\u201038\u00a0serum level in patients with vitiligo compared to healthy controls (Hcs) and examine the association between IL\u201038\u00a0level and severity and activity of vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The study comprised 21 patients with vitiligo and 21 Hcs. Vitiligo severity and activity were evaluated via Vitiligo Extent Score (VES) and Vitiligo Disease Activity (VIDA) Score, respectively. IL\u201038\u00a0serum level was evaluated by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitiligo patients had significantly higher serum level of IL\u201038 than Hcs (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). This level was significantly higher among patients with signs of vitiligo activity (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.048), correlated positively with VES (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and correlated negatively with the age of patients (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.001) and the age of disease onset (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u201038\u00a0serum level was higher in patients with vitiligo than in Hcs and was related to vitiligo severity and signs of activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14612","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T07:07:25Z","timestamp":1637046445000},"page":"3515-3521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Interleukin 38 serum level is increased in patients with vitiligo, correlated with disease severity, and associated with signs of disease activity"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8144-0926","authenticated-orcid":false,"given":"Radwa El\u2010 Sayed","family":"Mahmoud Marie","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u2010 Zahraa Mohamed","family":"Adel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Services Administration Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha M.","family":"Abd El\u2010 Fadeal","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology Faculty of Medicine Suez Canal University  Ismailia Egypt"},{"name":"Oncology Diagnostic Unit Faculty of Medicine Suez Canal University  Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa Mohamad Kamel","family":"Eyada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Suez Canal University  Ismailia 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