{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:26:32Z","timestamp":1787761592333,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scalp seborrheic dermatitis (SD) is a chronic inflammatory dermatosis associated with sebum imbalance and proliferation of <jats:italic>Malassezia<\/jats:italic> species. Various antifungal shampoos are commonly used for scalp SD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Glycyrrhetinic acid is known to have antioxidative, anti\u2010inflammatory, and anti\u2010allergic effects. This study was designed to evaluate the effectiveness of a new\u2010formula shampoo that contains glycyrrhetinic acid for the treatment of scalp SD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Thirty\u2010four patients were enrolled and treated with the 6% glycyrrhetinic acid complex shampoo. Efficacy was assessed clinically with Dermatology Life Quality Index (DLQI) and Adherent Scalp Flaking Score (ASFS) by the same dermatologist at baseline, week 2, and week 5. Among the 24 subjects with the most significant clinical improvement, four common microorganisms from scalp samples were analyzed by quantitative polymerase chain reaction (qPCR) at baseline, and week 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DLQI and ASFS at week 2 and week 5 improved significantly relative to baseline. The bacteria profiles showed a significant increase of <jats:italic>Cutibacterium acnes<\/jats:italic> and a decrease of <jats:italic>Staphylococcus epidermidis<\/jats:italic> at week 5. The fungi profiles showed significant decreases of both <jats:italic>Malassezia restricta<\/jats:italic> and <jats:italic>Malassezia globosa<\/jats:italic>. The ratio of <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acne<\/jats:italic> to <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>epidermidis<\/jats:italic> increased significantly from 0.93 at baseline to 1.55 at week 5. The ratio of <jats:italic>M<\/jats:italic>.\u00a0<jats:italic>restricta<\/jats:italic> to <jats:italic>M<\/jats:italic>.\u00a0<jats:italic>globosa<\/jats:italic> decreased from 5.02 at baseline to 1.00 at week 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effectiveness of this new regimen was objectively demonstrated at the clinical and microbiological levels. This new formula may alleviate the bacterial and fungal dysbiosis in scalp SD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14623","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T13:24:17Z","timestamp":1637241857000},"page":"3423-3430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of a new\u2010formula shampoo containing 6% glycyrrhetinic acid complex for scalp seborrheic dermatitis: A pilot study"],"prefix":"10.1111","volume":"21","author":[{"given":"Hsiao\u2010Chi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cosmetic Applications and Management Cardinal Tien Junior College of Healthcare and Management  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chii\u2010Shyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology En Chu Kong Hospital  New Taipei City 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