{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:58:04Z","timestamp":1790740684054,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Telogen Effluvium (TE) in a post\u2010Covid\u201019 patient causes excessive shedding of hair. No definite treatment is available till now. Past studies demonstrates that QR678Neo<jats:sup>\u00ae<\/jats:sup> has shown promising results in various types of Alopecia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this study, we aim to establish efficacy of QR678\u00a0Neo<jats:sup>\u00ae<\/jats:sup> hair growth factor formulation administration in Covid\u201019\u2010induced persistent TE for treatment of hair loss and for hair regrowth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material &amp; Method<\/jats:title><jats:p>Twenty adult patients (all females) presenting with persistent TE starting few weeks after recovery from Covid\u201019 infection, and continuing beyond 6\u00a0months were included for the study. A 1.5\u00a0mL solution of QR678\u00a0Neo<jats:sup>\u00ae<\/jats:sup> hair growth factor formulation was administered in the scalp per session. A total of 8\u00a0sessions (one session every 4\u00a0weeks) were done. The results were assessed at the baseline, after 4thsession, and 1\u00a0month after 8th session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most of the patients showed significant reduction in hair fall; 89% patients showed excellent hair growth. Global photographic assessment score showed marked improvement, which maintained even post therapy. Videomicroscopic assessment showed increase in the hair count (mean =29.32) after 8th session, that further improved even post therapy. The subjective assessment scores for overall hair growth, appearance of hair, reduction in visibility of the scalp, and hair loss were 4, 4.5, 4.25, and 5, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Management of Covid\u201019\u2010induced persistent Telogen Effluvium has been unclear and futile so far. Intra\u2010dermal administration of QR678\u00a0Neo<jats:sup>\u00ae<\/jats:sup> hair growth factor formulation in the scalp, reduces hair fall, improves hair regrowth, and increases the hair density.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14626","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T18:34:39Z","timestamp":1638902079000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of QR678 Neo<sup>\u00ae<\/sup> hair growth factor formulation for the treatment of hair loss in Covid\u201019\u2010induced persistent Telogen Effluvium\u2014A prospective, clinical, single\u2010blind study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-1170","authenticated-orcid":false,"given":"Debraj","family":"Shome","sequence":"first","affiliation":[{"name":"Department of Facial Plastic Surgery &amp; Facial Cosmetic Surgery The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinky","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cosmetic Dermatology &amp; Dermato\u2010Surgery The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Surana","sequence":"additional","affiliation":[{"name":"Department of Facial Plastic Surgery &amp; Facial Cosmetic Surgery The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Vadera","sequence":"additional","affiliation":[{"name":"Department of Facial Plastic Surgery &amp; Facial Cosmetic Surgery The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Shah","sequence":"additional","affiliation":[{"name":"Clinfotics LLP Vadodara India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.116731"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2010.00654.x"},{"key":"e_1_2_10_4_1","first-page":"1007","article-title":"Alopecia in women","volume":"67","author":"Thiedke CC","year":"2003","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1961.01580080005001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S200471"},{"key":"e_1_2_10_7_1","first-page":"389","article-title":"Telogen effluvium","volume":"27","author":"Harrison S","year":"2002","journal-title":"Clinexpdermatol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00003.x"},{"key":"e_1_2_10_9_1","first-page":"1","article-title":"Telogen effluvium: a review of the literature","volume":"12","author":"Asghar F","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_23_19"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1439965"},{"key":"e_1_2_10_12_1","first-page":"1","article-title":"QR678 & QR678 neo hair growth formulations: a cellular toxicity & animal efficacy study","volume":"8","author":"Kapoor R","year":"2020","journal-title":"Plast Reconstr Surg Global Open"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13398"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13673"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14630"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14139"},{"key":"e_1_2_10_17_1","unstructured":"ClinicA AsperA MittalA et al.Evaluation of safety and efficacy of intradermal administration of QR678 Neo\u00ae hair growth factor formulation\u2010 A Multi\u2010ethnicity Clinical Trial. Manuscript submitted to Journal of Cosmetic Dermatology for publication."},{"key":"e_1_2_10_18_1","unstructured":"ShomeD KapoorR DoshiK PatelG VaderaS KhamT.Evaluation of effectiveness of QR678\u00ae& QR678 Neo\u00ae hair growth factor formulation in post\u2010hair transplant patients. Manuscript submitted to Journal of Cosmetic Dermatology for publication."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444317633.ch66"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1959.156"},{"key":"e_1_2_10_21_1","first-page":"257","volume-title":"Disorders of hair growth","author":"Olsen E","year":"1994"},{"key":"e_1_2_10_22_1","first-page":"739","volume-title":"Conn\u2019s current therapy","author":"Shapiro J","year":"1996"},{"key":"e_1_2_10_23_1","first-page":"WE01","article-title":"Telogen effluvium: a review","volume":"9","author":"Malkud S","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2017.03.005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198801000-00020"},{"issue":"1","key":"e_1_2_10_26_1","article-title":"Telogen effluvium related to post severeCovid\u201019infection: clinical aspects and our management experience","volume":"34","author":"Rizzetto G","year":"2020","journal-title":"Dermatol Ther"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70049-9"},{"issue":"3","key":"e_1_2_10_28_1","first-page":"e181","article-title":"SARS\u2010CoV\u20102\u2010induced telogen effluvium: a multicentric study","volume":"35","author":"Moreno\u2010Arrones OM","year":"2020","journal-title":"JEADV"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15313"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.01.27.21250617"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14626","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T18:40:24Z","timestamp":1692816024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/jocd.14626"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14626","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]},"assertion":[{"value":"2021-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}