{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:57:51Z","timestamp":1790740671266,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia areata (AA) is an inflammatory disorder, marked by chronic, persistent, and patchy loss of hair. At present intralesional\/topical corticosteroids, Minoxidil solution, and topical immune\u2010therapies are used for treatment. Though all these have side effects and high rate of relapse. As QR678\u00a0Neo<jats:sup>\u00ae<\/jats:sup> is proved to be effective in hair regrowth in male and female pattern hair loss, the aim of the study is to compare the efficacy of QR678\u00a0Neo<jats:sup>\u00ae<\/jats:sup> with intralesional steroid therapy vs. intralesional steroid alone in the treatment of AA of scalp in men and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 20 participants in age group of 20\u201350\u00a0years with nonscarring patchy hair loss were chosen for the study. Patients were arbitrarily divided into two groups (Group A\u2014intralesional steroid with placebo and Group B\u2010intralesional steroid with QR678\u00a0Neo<jats:sup>\u00ae<\/jats:sup>). All the participants were evaluated at baseline, 3\u00a0months and 6\u00a0months with standard global photography, dermoscopic assessment, and self\u2010evaluation questionnaire at the end of study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Marked improvement was seen in the global assessment score after 6\u00a0months (mean\u2010 6.6 SALT) as compared to baseline (38.5 SALT score) in group B. There was significant reduction of black dots, yellow dots, broken hairs, and tapered hair at 6\u00a0months on video dermoscopic examination in group B. Also, higher satisfaction was experienced with the treatment in group B patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>QR678\u00a0Neo<jats:sup>\u00ae<\/jats:sup> in combination with intralesional steroids therapy proved to be significantly beneficial, efficient, and can be considered as safer treatment option for alopecia areata.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14630","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T12:13:04Z","timestamp":1637928784000},"page":"358-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effectiveness of QR678 and QR678 Neo<sup>\u00ae<\/sup> with intralesional corticosteroid vs. intralesional corticosteroid alone in the treatment of alopecia areata \u2013A randomized, comparative, prospective study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-1170","authenticated-orcid":false,"given":"Debraj","family":"Shome","sequence":"first","affiliation":[{"name":"Department of Facial Plastic Surgery &amp; Facial Cosmetic Surgery, Director The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinky","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cosmetic Dermatology &amp; Dermato\u2010Surgery The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Doshi","sequence":"additional","affiliation":[{"name":"Facial Plastic Surgery and Facial Cosmetic Surgery The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghanshyam","family":"Patel","sequence":"additional","affiliation":[{"name":"Biostatistician Veeda Clinical Research Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapna","family":"Vadera","sequence":"additional","affiliation":[{"name":"Facial Plastic Surgery and Facial Cosmetic Surgery The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-1740","authenticated-orcid":false,"given":"Vaibhav","family":"Kumar","sequence":"additional","affiliation":[{"name":"The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00127-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/983804"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4943"},{"key":"e_1_2_10_5_1","first-page":"23","article-title":"Area Celsi. 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