{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:39:56Z","timestamp":1782920396056,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study evaluated the efficacy of a dual\u2010wavelength 532\u00a0nm\/1064\u00a0nm Nd:YAG picosecond\u2010domain laser with a holographic lens array in treating facial photoaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen subjects were enrolled with 10 completing the study. Receiving three\u2010month treatments, subjects underwent full\u2010face spot treatment of facial lentigines with the 532\u2010nm non\u2010fractionated handpiece, followed by two sequential facial passes of the 1064\u2010nm and the 532\u2010nm fractionated handpieces. Improvement was measured by treating physician evaluation of pigmentation and rhytids as well as blinded reviewer evaluation of pre\u2010 and post\u2010treatment image sets taken 12\u00a0weeks after the final treatment. Participants completed treatment surveys to assess satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Physician grading on a 5\u2010point scale revealed an average improvement of 1.6 in pigmentation (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.0042) and 0.9 in rhytids (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.0196). Blinded physicians appropriately selected baseline images in 44 of 50 (88%) image sets (10\u00a0subjects; five reviewers). On an 11\u2010point scale for overall facial photoaging (0\u00a0=\u00a0no change, 1\u00a0=\u00a010% improvement, 2\u00a0=\u00a020% improvement, etc.) treating physicians scored mean improvement as 3.3\u00a0\u00b1\u00a01.83 (95% CI 1.99 to 4.61; range 1\u20136), while blinded reviewers scored mean improvement as 2.32\u00a0\u00b1\u00a02.62 (range % \u22124 to 8, 95% CI 1.57 to 3.07). The greatest majority (80%) of participants reported satisfaction with the treatment. Adverse events were mild; however, one patient developed hyperpigmentation, consistent with melasma that was successfully treated with topical agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to show that picosecond\u2010domain 532\u00a0nm\/1064\u00a0nm laser treatments with combination non\u2010fractionated and fractionated handpieces are well\u2010tolerated, safe, and effective for the treatment of photodamage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14654","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T11:20:38Z","timestamp":1639567238000},"page":"320-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of a dual\u2010wavelength 532\u00a0nm and 1064\u00a0nm picosecond\u2010domain laser with a fractionated holographic optic on photoaging and patient age perception: A pilot 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