{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:34:50Z","timestamp":1747186490415,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenetic alopecia (AGA) is the most common cause of hair loss in men. In addition to genetic and hormonal factors, oxidative stress (OS) is suggested as a factor in the etiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this study, we aimed to investigate the presence of OS due to thiol disulfide balance deterioration in male patients with AGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 45\u00a0male AGA patients and 42\u00a0healthy male controls were included in the study. Native thiol, disulfide, and total thiol levels were assessed through automated spectrophotometry. The relationship between total protein, albumin, native thiol, disulfide, and total thiol levels in addition to demographic and clinical characteristics of the patients were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 32.6\u00a0\u00b1\u00a010\u00a0years, and the median AGA duration in the patients was 3\u00a0years. There was no statistically significant difference in terms of native thiol, disulfide, total thiol levels, disulfide\/total thiol, disulfide\/native thiol, and native thiol\/total thiol ratios between AGA patients and controls. Native thiol and total thiol levels negatively correlated with age and AGA duration, while disulfide levels only correlated with age.Albumin and native thiol levels were significantly lower in patients with low vitamin D levels (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.040 and <jats:italic>p\u00a0<\/jats:italic>=\u00a00.021, respectively); however, total thiol and native thiol\/total thiol ratio values were significantly higher.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to this study, thiol disulfide homeostasis is in balance in male patients with AGA. In patients with emotional stress and vitamin D deficiency, the balance appears to be shifted in favor of oxidative stress.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14655","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T07:22:42Z","timestamp":1639034562000},"page":"3431-3437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of plasma thiol\/disulfide balance in male patients with androgenetic alopecia"],"prefix":"10.1111","volume":"21","author":[{"given":"Ay\u015fe","family":"Akba\u015f","sequence":"first","affiliation":[{"name":"Dermatology Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-2675","authenticated-orcid":false,"given":"Fadime","family":"K\u0131l\u0131n\u00e7","sequence":"additional","affiliation":[{"name":"Dermatology Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serta\u00e7","family":"\u015eener","sequence":"additional","affiliation":[{"name":"Dermatology Private Clinic  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cemile","family":"Bi\u00e7er","sequence":"additional","affiliation":[{"name":"Biochemistry Yildirim Beyazit University Medical Faculty  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funda","family":"Eren","sequence":"additional","affiliation":[{"name":"Biochemistry Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-7285","authenticated-orcid":false,"given":"Y\u0131ld\u0131z","family":"Hayran","sequence":"additional","affiliation":[{"name":"Dermatology Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ak\u0131n","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Dermatology Yildirim Beyazit University Medical Faculty  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12286"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/turkderm.48.s8"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"1","article-title":"Role of non androgenic factors in hair loss and hair regrowth","volume":"3","author":"Rajendrasingh JR","year":"2017","journal-title":"J Cosmo Trichol"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1280-y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197511000-00009"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3182439613"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2018.03.005"},{"issue":"3","key":"e_1_2_11_9_1","first-page":"331","article-title":"Oksidative stress and its impacts on intrasel\u00fcler lipits, proteins and DNA","volume":"6","author":"Erel \u00d6","year":"2015","journal-title":"JCEI"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2015.1121254"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12300"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2016.1240179"},{"issue":"1","key":"e_1_2_11_13_1","first-page":"12","article-title":"Dynamic thiol\/disulfide balance in patients with seborrheic dermatitis: a case\u2010control study. Saudi J Med","volume":"8","author":"Emre S","year":"2020","journal-title":"Med Sci"},{"key":"e_1_2_11_14_1","first-page":"134","article-title":"The formation and biochemistry of the hair.Turk Klin","volume":"1","author":"Ciliv G","year":"1998","journal-title":"J\u00a0Cosmetol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.28"},{"issue":"3","key":"e_1_2_11_16_1","first-page":"443","article-title":"Protein Tiyols as an indication of oxidative stres","volume":"23","author":"Chianeh YR","year":"2014","journal-title":"Archives Medical Review Journal"},{"key":"e_1_2_11_17_1","first-page":"83","article-title":"Basic mechanisms of protein oxidation","volume":"35","author":"Kayal\u0131 R","year":"2004","journal-title":"Cerrahpa\u015fa J Med"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4039fje"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2019.81685"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.9734\/BJMMR\/2017\/33535"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_78_17"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00015-4"},{"issue":"1","key":"e_1_2_11_23_1","first-page":"79","article-title":"Oxidative stress in androgenetic alopecia","volume":"9","author":"Prie BE","year":"2016","journal-title":"J Med Life"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.09.026"},{"issue":"2","key":"e_1_2_11_25_1","first-page":"33","article-title":"Androgen\u2010inducible TGF\u2010beta1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understand paradoxical effects of intrinsic skin aging the role of oxidative stres","volume":"21","author":"Inui S","year":"2012","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_57_18"},{"key":"e_1_2_11_27_1","unstructured":"Nazik S Kiraz ZK Demir B Erken ba\u015flang\u0131\u00e7l\u0131 androgenetik alopeside iskemi modifiye alb\u00fcmin d\u00fczeyi ve OS ile ili\u015fkili parametrelerin de\u011ferlendirilmesi \/turkderm\u2010deri\u2010hastaliklari \u0131klar\u0131 \u2010ve\u2010frengi\u2010arsivi\" ve Frengi Ar\u015fivi2017:\u00a051Say\u0131:\u00a04ISSN:\u00a01019\u2010214X \/ 1308\u20106294 S.115 \u2010 118"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-2003-64"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2018.76227"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.4274\/meandros.48303"},{"key":"e_1_2_11_31_1","first-page":"1","article-title":"Dynamic thiol\/disulfide homeostasis and effects of smoking on homeostasis parameters in patients with psoriasis","volume":"25","author":"Emre S","year":"2017","journal-title":"Cutan Ocul Toxicol"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13732"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701147"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom5020545"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.036"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0323-8"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14982"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010020\u201002468\u20102"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.5336\/dermato.2020\u201080196"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.4274\/tdd.2810"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011315"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14655","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T03:02:47Z","timestamp":1692500567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,8]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jocd.14655"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14655","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2021,12,8]]},"assertion":[{"value":"2021-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}