{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:29:36Z","timestamp":1771489776818,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T00:00:00Z","timestamp":1639267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Botulinum neurotoxin A injection is a popular noninvasive alternative for the treatment of masseter hypertrophy. This study was conducted to identify a safe injection volume to avoid sunken lateral cheek after botulinum neurotoxin A injection in the masseter muscle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One milliliter or 0.5\u00a0ml of indocyanine green was randomly injected into either side of the masseter muscles of 18 fresh cadaver heads. The bilateral spreads of indocyanine green within the masseter were observed by a fluorescence imager. The masseters were then dissected, and the spreading distance was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dye spreading showed an oval shape parallel to the long axis of the masseter muscle. The lower edges of the masseters were all stained with indocyanine green. The upward spreading exceeded the mouth corner\u2010tragus line in 94.44% (17\/18) of the masseters on the 1\u2010ml side, and 11.11% (2\/18) of the masseters on the 0.5\u2010ml side. The spreading area and upward spreading distance on the 1\u2010ml side (9.95\u00a0\u00b1\u00a00.48\u00a0cm<jats:sup>2<\/jats:sup>, 3.18\u00a0\u00b1\u00a00.31\u00a0cm) were significantly larger than the 0.5\u2010ml side (7.13\u00a0\u00b1\u00a00.80\u00a0cm<jats:sup>2<\/jats:sup>, 2.08\u00a0\u00b1\u00a00.32\u00a0cm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The spread of indocyanine green within the masseter occurs in direct proportion to its volume. A bolus of 1\u00a0ml easily exceeded the mouth corner\u2010tragus line and cause sunken cheek.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14658","type":"journal-article","created":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T14:30:35Z","timestamp":1639319435000},"page":"137-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pivotal role of injection volume on sunken cheek prevention in masseter muscle BoNT\u2010A injection: A cadaver study"],"prefix":"10.1111","volume":"21","author":[{"given":"Panxi","family":"Yu","sequence":"first","affiliation":[{"name":"The 16th Department Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixin","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijia","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Beijing Tsinghua Changgung Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Communication University of China Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7908","authenticated-orcid":false,"given":"Yunzhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Anatomy Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-2508","authenticated-orcid":false,"given":"Xiao","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanze","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001859"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005083"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12721"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000371"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12473"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.120"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25582"},{"key":"e_1_2_10_9_1","first-page":"CD007510","article-title":"Botulinum toxin for masseter hypertrophy","volume":"21","author":"Al\u2010Muharraqi MA","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29117.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-007-0081-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2009.11.014"},{"key":"e_1_2_10_13_1","first-page":"2801","article-title":"Automatic masseter thickness measurement and ideal point localization for botulinum toxin injection. 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