{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:51:31Z","timestamp":1785876691170,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Various systemic agents have been assessed for treatment of alopecia areata; however, there is a paucity of comparative studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the efficacy of azathioprine versus mesalazine in the treatment of severe alopecia areata.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study was carried out in 30 patients with severe alopecia areata divided into two groups, group A: fifteen patients were treated by azathioprine in an oral dose of 1\u20132\u00a0mg\/kg\/day and group B: fifteen patients were treated by mesalazine in an oral dose of 15\u201330\u00a0mg\/kg\/day in two divided doses. The treatment was considered effective if percentage regrowth of hair was determined by change in SALT score &gt;50 from base line after 6\u00a0months of treatment. The treatment was continued for 3\u20136\u00a0months after complete remission to minimize the risk of relapse. The dose was gradually tapered during this time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study found that there is statistically significant difference between mean SALT scores before treatment and after 6\u00a0months of treatment in both groups. In group A, SALT score at base line was 84.42\u00a0\u00b1\u00a017.41, after 6\u00a0months it was 35.95\u00a0\u00b1\u00a035.79 (<jats:italic>p<\/jats:italic> value 0.04). In group B, SALT score at base line was 73.06\u00a0\u00b1\u00a022.10, after 6\u00a0months it was 23.04\u00b1 12.27 (<jats:italic>p<\/jats:italic> value 0.037). Changes in SALT score after 6\u00a0months were \u221227.74\u00a0\u00b1\u00a020.66 in group A and \u221260.42\u00b138.41 in group B (<jats:italic>p<\/jats:italic> value 0.055).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mesalazine may be considered as effective as azathioprine with lesser side effects. Azathioprine is also considered safe. However, a large group study should be performed to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14687","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T07:59:23Z","timestamp":1639727963000},"page":"3444-3450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparative study between the efficacies of azathioprine and mesalazine in the treatment of severe alopecia areata"],"prefix":"10.1111","volume":"21","author":[{"given":"Randa Al Sayed","family":"Mahgoob","sequence":"first","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Kotor hospital Ministry of health and Population  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad Eldin","family":"Elgamal","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Damitta Faculty of Medicine Al \u2010Azhar University  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama Magdy","family":"Elshahat","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Damitta Faculty of Medicine Al \u2010Azhar University  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir Atef","family":"Almetwaly","sequence":"additional","affiliation":[{"name":"Forensic medicin and Clinical toxicology Department Damitta, Faculty of Medicine Al \u2010Azhar University  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14497"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.11"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.055"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12941"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.04.1141"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_57_19"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15099"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3645"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04576.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.10.980"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_14_18"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.031"},{"issue":"5","key":"e_1_2_9_14_1","first-page":"893","article-title":"The role of mesalamine in the treatment of ulcerative colitis","volume":"3","author":"Karagozian R","year":"2007","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.032"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14687","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T03:02:59Z","timestamp":1692500579000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jocd.14687"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14687","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]},"assertion":[{"value":"2021-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}