{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T21:39:54Z","timestamp":1768945194031,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Updates of treatment methods of stable vitiligo are needed to give better outcomes with a shorter duration of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the effect of transdermal 5\u2010fluorouracil (5\u2010FU) delivery using fractional CO<jats:sub>2<\/jats:sub>(FrCO<jats:sub>2<\/jats:sub>) laser versus intralesional 5\u2010FU injection, with narrow\u2010band type ultraviolet B (UVB) (NB\u2010UVB) therapy after both, in the treatment of stable vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>The present study comprised 40 patients with nearly symmetrical stable vitiligo lesions. The left side was treated with FrCO<jats:sub>2<\/jats:sub>\u00a0laser followed by topical 5\u2010FU (FrCO<jats:sub>2<\/jats:sub>\u00a0+\u00a05\u2010FU), while the right side was treated with 5\u2010FU intradermal injection. Both procedures were done at 2\u2010week intervals for 3\u00a0sessions followed by 24\u00a0sessions of narrow\u2010band UVB for both sides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Repigmentation was demonstrated on the left side of 90% of patients and the right side of 85% of patients. As much as &gt;50% improvement was demonstrated on the left side of 50% of patients, and the right side of 55% of patients. Intralesional 5\u2010FU showed a statistically significant difference in repigmentation compared to FrCO<jats:sub>2<\/jats:sub>\u00a0+\u00a05\u2010FU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both 5\u2010FU injection and FrCO<jats:sub>2<\/jats:sub>\u00a0+\u00a05\u2010FU were effective therapeutic modalities for vitiligo. Patients were more compliant with FrCO<jats:sub>2<\/jats:sub>\u00a0+\u00a05\u2010FU.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14691","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T10:05:15Z","timestamp":1641809115000},"page":"3832-3841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment of stable nonsegmental vitiligo using transdermal delivery of 5\u2010fluorouracil by fractional CO<sub>2<\/sub>laser versus intralesional injection of 5\u2010fluorouracil, both followed by narrow\u2010band type ultraviolet B (UVB): A comparative study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-4751","authenticated-orcid":false,"given":"Lamia H.","family":"Elgarhy","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine Tanta University Tanta 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