{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:09:51Z","timestamp":1767704991334,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Unlike various topical treatment options for acne vulgaris, options for acne scars mostly involve invasive interventions. So far, only a few clinical trials have investigated the effects of topical treatment for acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We evaluated the safety and efficacy of DA\u20105520, a recently developed topical gel for the treatment of different types of acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 12\u2010week prospective, randomized, active\u2010controlled, evaluator\u2010blind, single\u2010center study involving 36 participants with acne scars was performed. Participants were randomized into four different groups at a 1:1:1:1 ratio: laser resurfacing with DA\u20105520 application (test 1); laser resurfacing without DA\u20105520 application (control 1); comedone extraction with DA\u20105520 application (test 2); and comedone extraction without DA\u20105520 application (control 2). For 12\u00a0weeks, participants in the two test groups applied DA\u20105520 twice daily, while participants in the control groups applied moisturizers alone. Participants in the test 1 and control 1\u00a0groups received a single session of laser resurfacing at visit 1 (week 0). All participants were followed up at 1, 4, 8, and 12\u00a0weeks, and objective scar evaluation using the \u00e9chelle d\u2019\u00e9valuation clinique des cicatrices d'acn\u00e9 (ECCA) score was performed at each visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical improvement of acne scars, confirmed by the ECCA grading scale (1 for atrophic scar and 2 for hypertrophic scar), was observed after using DA\u20105520 when combined with laser resurfacing or individually, and no associated adverse reactions were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preliminary results of this study revealed that DA\u20105520\u00a0may be a promising new formulation for treating all type of acne scars.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14693","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T14:19:52Z","timestamp":1641305992000},"page":"3888-3895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single\u2010center, assessor\u2010blind study to evaluate the efficacy and safety of DA\u20105520 topical gel in patients with acne scars: A pilot study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3556-0740","authenticated-orcid":false,"given":"Hye Sung","family":"Han","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine Chung\u2010Ang University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2690-6495","authenticated-orcid":false,"given":"Jae Wan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Chung\u2010Ang University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-8174","authenticated-orcid":false,"given":"Sun Hye","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Chung\u2010Ang University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Ho","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Chung\u2010Ang University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sung","family":"Sohn","sequence":"additional","affiliation":[{"name":"Medical information &amp; Clinical research Dong\u2010A Pharm. 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