{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:58:16Z","timestamp":1790740696164,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Intradermal administration of QR678 Neo\n                      <jats:sup>\u00ae<\/jats:sup>\n                      hair re\u2010growth factor formulation has already proven its effectiveness and safety in treating androgenetic alopecia and female pattern hair loss.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aims to evaluate effectiveness and safety of hair re\u2010growth factor formulation at multiple centers for reduction of hair fall and regrowth of hair in androgenetic alopecia and female pattern hair loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>An open\u2010label, prospective, and interventional study was carried out at multiple centers of different countries. A total of 2428 patients with androgenetic alopecia and female pattern hair loss within the age range of 18\u201365\u00a0years were included in the study. Hair pull test, global photographic assessment, videomicroscopic assessment tests were performed at the beginning, after fourth and eighth sessions, and self\u2010assessment through questionnaire related to satisfaction and side effects was carried out at beginning and at after eight session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hair pull test was positive in only 12% of the patients after eight sessions. Beneficial results were noted in the global assessment score (mean\u20106) after fourth session and eighth session (mean\u20108). Huge improvement was noted in terminal hair count, vellus hair count, and hair density after eighth sessions. Also, with self\u2010assessment score, a higher satisfaction score was noted. On long\u2010term follow\u2010up as well, no side effects were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Intradermal administration of QR678 Neo\n                      <jats:sup>\u00ae<\/jats:sup>\n                      is an innovative, efficacious, and safe technique for the treatment of androgenetic alopecia and female pattern hair loss.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14715","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T13:48:21Z","timestamp":1641649701000},"page":"580-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of the safety and effectiveness of intradermal administration of QR678 Neo\n                    <sup>\u00ae<\/sup>\n                    hair growth factor formulation: A phase\u2010IV, open\u2010label, single\u2010arm multi\u2010ethnicity clinical trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Aayna","family":"Clinic","sequence":"first","affiliation":[{"name":"Consultants, Aayna Clinics New Delhi &amp; Ludhiana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Asper","sequence":"additional","affiliation":[{"name":"Renew Aesthetics and IV Hydration Bar Couer d'Alene ID USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apoorva","family":"Mittal","sequence":"additional","affiliation":[{"name":"Thind Eye Hospital Jalandhar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-1170","authenticated-orcid":false,"given":"Debraj","family":"Shome","sequence":"additional","affiliation":[{"name":"Department of Facial Plastic and Facial Cosmetic Surgery &amp; Director The Esthetic Clinics Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Parbhoo","sequence":"additional","affiliation":[{"name":"Dr Deepa Parbhoo Aesthetics Sandton South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Thanzama","sequence":"additional","affiliation":[{"name":"Blue Mountain Pharmacy and Skin &amp; 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