{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:28:25Z","timestamp":1773883705981,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Facial papules reflecting the lichenoid inflammation of facial vellus hair follicles can occur in the backgrounds of frontal fibrosing alopecia, lichen planopilaris (LPP), or even alone. In the present study, we aimed to compare systemic and topical isotretinoin in the treatment of facial LPP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In a prospective randomized trial, 26 patients with facial LPP were randomly allocated to receive either 20\u00a0mg\/day oral isotretinoin or isotretinoin 0.05% gel every night for 6\u00a0months. Global Aesthetic Improvement Scale (GAIS) and patient's satisfaction questionnaire were used at 1, 3, and 6\u00a0months after treatment to evaluate the outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both oral and topical isotretinoin groups, facial papules were significantly improved at all follow\u2010up visits, resulting in statistically significant improvements (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007, respectively, for oral and topical groups) in GAIS score mean difference from month 1 to month 6. Overall levels of patient satisfaction were high in both groups, and no\u00a0significant\u00a0difference was observed between two groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.107). However, the mean GAIS score at 3 and 6\u00a0months after treatment showed significantly greater improvements in oral isotretinoin group compared to topical group (1.85\u00a0\u00b1\u00a00.62 vs. 1.03\u00a0\u00b1\u00a00.49 at month 3, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004; 2.45\u00a0\u00b1\u00a054 vs. 1.59\u00a0\u00b1\u00a00.62 at month 6, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). Overall, patients could well tolerate the treatments; however, topical therapy was associated with fewer side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Both oral and topical isotretinoin were found to be effective in improving facial papules; however, oral isotretinoin was significantly more efficacious. Considering safety profile of topical isotretinoin, it can be administrated as maintenance therapy for patients with facial LPP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14730","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T15:30:56Z","timestamp":1641310256000},"page":"3896-3904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of systemic and topical isotretinoin in the treatment of facial lichen planopilaris: A randomized controlled trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Mina","family":"Saber","sequence":"first","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Bahraminejad","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farahnaz","family":"Fatemi Naeini","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Mohaghegh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gita","family":"Faghihi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayed Mohsen","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Biostatics and Epidemiology School of Public Health Isfahan University of Medical Sciences  Isfahan 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