{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T01:17:57Z","timestamp":1752283077085,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acanthosis nigricans (AN) is a common dermatosis that presents with hyperpigmented, velvety thick plaques over intertriginous areas. Though a number of treatment modalities including chemical peels have been used, none provide long\u2010term and sustained improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim and objectives<\/jats:title><jats:p>Our study evaluated the efficacy and safety of regular sessions of salicylic acid\u2010mandelic acid peeling over axillary AN lesions, which was followed by daily application of a topical combination of glycolic acid, urea, and cetylated fat esters for maintenance of effect for 9\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>A retrospective pilot study was conducted in Indian patients (Fitzpatrick skin type 4 or 5), aged 18\u201350 with benign hereditary AN involving the underarms, with or without affection of other typical sites. Data were retrieved of seventeen patients with AN involving the axillae. Patients were started on combination salicylic\u2010mandelic acid peel given every 2\u00a0weeks for a total of 6\u00a0sessions. Maintenance was done by night application of combination cream of glycolic acid, urea, and cetylated fat esters, which was continued for 9\u00a0months after completion of peeling sessions. Lesions were evaluated every 3\u00a0months of 9\u00a0months for improvement in pigmentation and skin thickening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the patients (100%) showed significant improvement in both pigmentation and thickening of lesions. In terms of improvement in skin thickening, very good improvement was seen in 41%, while 29% patients had moderate improvement. In terms of improvement in pigmentation, 35% each had very good and moderate improvement. Post peel erythema (100%) and burning sensation (90%) were the most common encountered adverse effects which lasted for only 1\u20132\u00a0days. Patients were followed up for another 9\u00a0months during which no relapses were seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combination of keratolytic chemical peels and topical mild keratolytic application ensures better therapeutic outcome in patients of AN with long lasting effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14731","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T15:44:13Z","timestamp":1640965453000},"page":"3905-3909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Treatment of acanthosis nigricans with sequential salicylic acid\u2010mandelic acid combination peel and maintenance with glycolic acid\u2010urea combination cream: A retrospective pilot study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3159-1045","authenticated-orcid":false,"given":"Md","family":"Zeeshan","sequence":"first","affiliation":[{"name":"Department of Skin &amp; V.D Patna Medical College and Hospital  Patna India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noorussaba","family":"Arfeen","sequence":"additional","affiliation":[{"name":"Department of General Medicine All India Institute of Medical Sciences  Patna India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidharth","family":"Sonthalia","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Dermatosurgery SKINNOCENCE; The Skin Clinic &amp; Research Centre  Gurugram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7576-3956","authenticated-orcid":false,"given":"Anupama","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Skin &amp; V.D Patna Medical College and Hospital  Patna India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasoon Kumar","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Skin &amp; V.D Nalanda Medical College and Hospital  Patna India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.137765"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1976.tb04895.x"},{"key":"e_1_2_11_4_1","first-page":"159","article-title":"Topical tretinoin in acanthosis nigricans","volume":"62","author":"Lahiri K","year":"1996","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630802050506"},{"key":"e_1_2_11_6_1","first-page":"884","article-title":"Comparison of metformin versus rosiglitazone in patients with acanthosis nigricans: a pilot study","volume":"5","author":"Bellot\u2010Rojas P","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1980.01640250112027"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.124.7.1094"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30346.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.674194"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.10.1655"},{"key":"e_1_2_11_12_1","first-page":"299","article-title":"Generalized acanthosis nigricans related to type B insulin resistance syndrome: a case report","volume":"86","author":"Jeong KH","year":"2010","journal-title":"Cutis"},{"key":"e_1_2_11_13_1","first-page":"33","article-title":"Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity","volume":"71","author":"Blostein SH","year":"2003","journal-title":"Cutis"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02538.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13580"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32075.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4172\/2376-0427.1000162"},{"issue":"1","key":"e_1_2_11_18_1","first-page":"59","article-title":"Glycolic acid peels versus salicylic\u2010mandelic acid peels in active acne vulgaris and post\u2010acne scarring and hyperpigmentation: a comparative study","volume":"35","author":"Garg VK","year":"2009","journal-title":"Dermatol Surg"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14731","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14731","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T18:12:15Z","timestamp":1692468735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,31]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/jocd.14731"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14731","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2021,12,31]]},"assertion":[{"value":"2021-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}