{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:02:07Z","timestamp":1773799327819,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Acne vulgaris is a multifactorial disease of the pilosebaceous unit. As the most common skin disease, it may affect approximately 85% of the young population. Survivin, a member of the inhibitors of the apoptosis (IAP) gene family, can inhibit apoptosis and regulate cell division and proliferation. In the study, we aimed to investigate the potential role of serum survivin in acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty individuals\u00a0who were diagnosed with acne vulgaris and forty healthy subjects as the control group were enrolled in the study. Venous blood samples were collected from each participant, and the serum levels of survivin were measured by enzyme\u2010linked immunosorbent assay (ELISA). Statistical analysis was performed using SPSS software version 25.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum survivin levels were statistically significant between the groups, and the levels of survivin were measured as acne vulgaris patients group 153.44 and control group 104.17\u00a0pg\/ml, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.018). When the serum survivin levels were compared according to gender, females had higher levels of survivin than the males (168.16 versus 50.45\u00a0pg\/mL, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). A significant correlation was found between acne severity (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.017) and Scale for Acne Scar severity (SCAR\u2010S) score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) according to the survivin levels. In terms of age, no significant relationship was found between age and survivin (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.4048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated serum levels of survivin were determined in acne vulgaris. Moreover, there was a significant correlation between acne stage and SCAR\u2010S score according to survivin levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14742","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T08:53:11Z","timestamp":1642409591000},"page":"1744-1748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Elevated survivin levels in patients with acne vulgaris"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-4561","authenticated-orcid":false,"given":"G\u00fclhan","family":"Aksoy Sara\u00e7","sequence":"first","affiliation":[{"name":"Department of Dermatology Ufuk University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0646-946X","authenticated-orcid":false,"given":"Saadet","family":"Kader","sequence":"additional","affiliation":[{"name":"Karap\u0131nar State Hospital Biochemistry Laboratory Karap\u0131nar  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-6751","authenticated-orcid":false,"given":"Turan","family":"Akda\u011f","sequence":"additional","affiliation":[{"name":"Meram Vocational School Necmettin Erbakan University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"495","volume-title":"Dermatology","author":"Zaenglein AL","year":"2008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06078.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922808315444"},{"key":"e_1_2_10_5_1","first-page":"690","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"Zanglein AL","year":"2008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2007.07.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339406777592113"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.12.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.90"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.279"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2010.09037"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.09.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)80056-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03919.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.199581"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14409"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.5455\/jmp.20130127102901"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijap.2020.v12s3.39462"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21560"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13590"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01273.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/2059513118818031"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2020.115635"},{"key":"e_1_2_10_25_1","first-page":"401","article-title":"The effect of Forkhead box class O1, mammalian target of rapamycin complex 1, survivin, and interleukin\u201017 on the degree of acne vulgaris based on serum levels. 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