{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T07:50:29Z","timestamp":1748418629848,"version":"3.41.0"},"reference-count":6,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and objective<\/jats:title><jats:p>Efficacy of cosmetic routines is reportedly available in several dermatological conditions, such as acne or rosacea. However, clinical evidence about objective advantages of skincare routine remains limited despite advertising often claims benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We aimed to assess the subject satisfaction level and the benefit from daily use of an advanced skincare routine named Method R. We used four different approaches to try and demonstrate the efficacy of the method: Transdermal delivery test, ex\u2010vivo efficacy test, Visioscan<jats:sup>\u00ae<\/jats:sup> VC 20, and patient survey. MetR consists of a six\u2010step routine that shows an increased epidermal penetration and activity due to liposomation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transdermal delivery test and ex\u2010vivo efficacy test show increased efficacy for liposomated actives. The skincare routine is well tolerated, and is associated with a marked efficacy in global quality of skin, dyschromia\/pigmentation, brightness, and hydration according to patient perception. The subject satisfaction level is high and the routine is safe. The continuous use of the routine for one month or more results in objective changes when measured with Visioscan<jats:sup>\u00ae<\/jats:sup> VC 20 plus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14747","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T14:54:20Z","timestamp":1642949660000},"page":"4422-4432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Method R: Efficacy of a cosmetic routine comprising six topical lipid\u2010encapsulated products"],"prefix":"10.1111","volume":"21","author":[{"given":"Rebeca","family":"Alonso\u2010Bartolom\u00e9","sequence":"first","affiliation":[{"name":"Nanovex Biotechnologies  Asturias Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Pando","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Nanovex Biotechnologies  Asturias Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-3027","authenticated-orcid":false,"given":"Pedro","family":"Rodr\u00edguez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Dermatology Unit Clinica Dermatologica Internacional  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ruiz\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Dermatology Unit Clinica Dermatologica Internacional  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12250"},{"key":"e_1_2_10_4_1","first-page":"22","article-title":"Efficacy, safety, and subject satisfaction of a specified skin care regimen to cleanse, medicate, moisturize, and protect the skin of patients under treatment for acne vulgaris","volume":"8","author":"Del Rosso JQ","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S125438"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.10.023"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15928"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:46:04Z","timestamp":1748353564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,23]]},"references-count":6,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/jocd.14747"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14747","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2022,1,23]]},"assertion":[{"value":"2021-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}