{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:45:24Z","timestamp":1791938724017,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2020SF\u2010224"],"award-info":[{"award-number":["2020SF\u2010224"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is a common chronic inflammatory cutaneous disorder that has a higher prevalence in adolescents and young adults. Previous studies have indicated that both genetic and environmental factors contribute to its risk. The protein encoded by the <jats:italic>TIMP2<\/jats:italic>\u00a0gene is a natural inhibitor of matrix metalloproteinases (MMPs). Changes in <jats:italic>TIMP2 expression<\/jats:italic> are speculated to disrupt the TIMP\/MMP balance and result in acne scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Our study aimed to comprehensively explore the potential genetic susceptibility of <jats:italic>TIMP2<\/jats:italic> to acne scarring based on a case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>In total, 1060 patients with acne scarring (cases) and 2162 patients without acne scarring (controls) were enrolled in the present study. Seventeen tag single\u2010nucleotide polymorphisms (SNPs) in the <jats:italic>TIMP2<\/jats:italic>\u00a0gene were selected for genotyping. Genetic association analyses were conducted at both the single marker and haplotypic levels. Single marker\u2010based association analyses were performed in the genotypic model and allelic model. The distributions of clinical variables in different genotype groups of targeted SNPs in patients with acne scarring were also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SNP rs4789932 was identified to be significantly associated with the risk of acne scarring in both the genotypic model (<jats:italic>p<\/jats:italic> = 0.001) and allelic model (<jats:italic>p<\/jats:italic> = 0.0002). The C allele of SNP rs4789932 was significantly associated with an increased risk of acne scarring (OR [95% CI] = 1.23 [1.10\u20131.37]). Significant differences were identified between the SNP rs4789932\u00a0genotypes and the clinical severity of acne scarring (<jats:italic>p<\/jats:italic> &lt; 2.2 \u00d7 10<jats:sup>\u221216<\/jats:sup>). The C allele of SNP rs4789932 was associated with severe clinical features of acne scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant genetic marker of the promoter region in <jats:italic>TIMP2<\/jats:italic> was identified to contribute to the risk of acne scarring in the Chinese Han population and was significantly associated with the clinical severity of acne scarring in patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14749","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T15:19:03Z","timestamp":1642000743000},"page":"4740-4747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>TIMP2<\/i> genetic variation rs4789932 may associate with an\u00a0increased risk of developing acne scarring based on a case\u2010control study of Chinese Han population"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiulin","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Plastic, Aesthetic and Maxillofacial Surgery The First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi'an China"},{"name":"Department of Nursing The First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huicong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic and Maxillofacial Surgery The First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic and Maxillofacial Surgery The First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic and Maxillofacial Surgery The First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic and Maxillofacial Surgery The First Affiliated Hospital of Xi\u2019an Jiaotong University  Xi'an 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